Neurons in the frontal lobe encode the value of multiple decision variables.

Neurons in the frontal lobe encode the value of multiple decision variables.
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额叶中的神经元编码多个决策变量的值。

DOI:
10.1162/jocn.2009.21100
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发表时间:
2009-06
影响因子:
3.2
通讯作者:
Wallis JD
Wallis JD
中科院分区:
医学3区
文献类型:
--
作者:
Kennerley SW;Dahmubed AF;Lara AH;Wallis JD

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行为科学的一个核心问题是,我们如何在各种选择中进行选择,以始终获得最有益的结果。在做决策时,有三个变量特别重要:潜在的回报、成功的可能性以及时间和精力的成本。决策过程中的一个关键大脑区域是额叶皮层,因为这里的损伤会削弱在一系列决策类型中做出最佳选择的能力。当受试者做出涉及上述三个决策变量的选择时,我们同时记录了额叶皮质中多个单神经元的活动。这使我们能够对比前扣带皮层(ACC)、眶额皮层和外侧前额叶皮层对决策过程的相对贡献。所有这三个区域的神经元都对涉及概率、回报或成本操纵的选择进行编码。然而,最重要的信号是在ACC中,其中神经元编码三个不同决策变量的多路复用表示。这支持了这样一种观点,即ACC是最佳决策背后的神经回路的重要组成部分。
A central question in behavioral science is how we select among choice alternatives to obtain consistently the most beneficial outcomes. Three variables are particularly important when making a decision: the potential payoff, the probability of success, and the cost in terms of time and effort. A key brain region in decision making is the frontal cortex as damage here impairs the ability to make optimal choices across a range of decision types. We simultaneously recorded the activity of multiple single neurons in the frontal cortex while subjects made choices involving the three aforementioned decision variables. This enabled us to contrast the relative contribution of the anterior cingulate cortex (ACC), the orbito-frontal cortex, and the lateral prefrontal cortex to the decision-making process. Neurons in all three areas encoded value relating to choices involving probability, payoff, or cost manipulations. However, the most significant signals were in the ACC, where neurons encoded multiplexed representations of the three different decision variables. This supports the notion that the ACC is an important component of the neural circuitry underlying optimal decision making.
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