Building a better hormone therapy? How understanding the rapid effects of sex steroid hormones could lead to new therapeutics for age-related memory decline.
Building a better hormone therapy? How understanding the rapid effects of sex steroid hormones could lead to new therapeutics for age-related memory decline.
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DOI：
10.1037/a0026660
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发表时间：
2012-02
影响因子：
1.9
通讯作者：
Frick, Karyn M.
中科院分区：
文献类型：
--
作者：
Frick, Karyn M.
近几十年来收集的大量数据表明，卵巢性类固醇激素，特别是17β-雌二醇（E2），是调节大脑认知区域（如海马）功能的重要营养因子。绝经期激素循环的丧失与女性的认知能力下降和痴呆有关，并且与动物模型中记忆力下降的开始有关。然而，激素疗法目前不推荐用于预防或治疗认知能力下降，部分原因是其有害的副作用。在这篇文章中，它是建议的调查E2对海马功能的快速影响，以进一步设计新的药物，模仿E2对记忆的有益作用，而没有目前治疗的副作用。提出了一个概念模型，阐明性类固醇激素调节记忆的分子和生化机制，并提出了一个具体的假设来解释E2的快速记忆增强作用。这一假设的实证支持进行了讨论，作为一种手段，刺激考虑新的发展方向，以保持更年期妇女的记忆功能，以女性为基础的治疗。
A wealth of data collected in recent decades has demonstrated that ovarian sex-steroid hormones, particularly 17β-estradiol (E2), are important trophic factors that regulate the function of cognitive regions of the brain such as the hippocampus. The loss of hormone cycling at menopause is associated with cognitive decline and dementia in women, and the onset of memory decline in animal models. However, hormone therapy is not currently recommended to prevent or treat cognitive decline, in part because of its detrimental side effects. In this article, it is proposed that investigations of the rapid effects of E2 on hippocampal function be used to further the design of new drugs that mimic the beneficial effects of E2 on memory without the side effects of current therapies. A conceptual model is presented for elucidating the molecular and biochemical mechanisms through which sex-steroid hormones modulate memory, and a specific hypothesis is proposed to account for the rapid memory-enhancing effects of E2. Empirical support for this hypothesis is discussed as a means of stimulating the consideration of new directions for the development of hormone-based therapies to preserve memory function in menopausal women.
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