Aging alters the expression of genes for neuroprotection and synaptic function following acute estradiol treatment.
Aging alters the expression of genes for neuroprotection and synaptic function following acute estradiol treatment.
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DOI：
10.1002/hipo.20703
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发表时间：
2010-09
期刊：
影响因子：
3.5
通讯作者：
Foster, Thomas C.
中科院分区：
文献类型：
--
作者：
Aenlle, Kristina K.;Foster, Thomas C.
本研究利用微阵列分析来检测卵巢切除小鼠单次注射雌二醇后6小时和12小时基因表达的年龄相关变化。与年轻（4个月）和中年（12个月）小鼠相比，老年（18个月）动物在6小时时间点的雌二醇反应性基因表达降低。对生物学和功能通路内基因聚类的检测表明，年轻和中年小鼠表现出突触细胞成分相关基因表达增加，以及与氧化磷酸化和线粒体功能障碍相关基因表达降低。在12小时时间点，与6小时时间点相比，老年动物的雌二醇反应性基因表达增加，而年轻和中年小鼠则降低。基因聚类分析表明，老年小鼠表现出受雌二醇快速影响的信号通路相关基因表达增加。快速信号通路基因表达的年龄差异可能与基础通路活性的差异以及雌二醇介导的快速信号级联激活有关。
This study used microarray analysis to examine age-related changes in gene expression 6 and 12 hr following a single estradiol injection in ovariectomized mice. Estradiol-responsive gene expression at the 6 hr time point was reduced in aged (18 mo) animals compared to young (4 mo) and middle-aged (MA, 12 mo) mice. Examination of gene clustering within biological and functional pathways indicated that young and MA mice exhibited increased expression of genes for cellular components of the synapse and decreased expression of genes related to oxidative phosphorylation and mitochondrial dysfunction. At the 12 hr time point, estradiol-responsive gene expression increased in aged animals and decreased in young and MA mice compared to the 6 hr time point. Gene clustering analysis indicated that aged mice exhibited increased expression of genes for signaling pathways that are rapidly influenced by estradiol. The age differences in gene expression for rapid signaling pathways may relate to disparity in basal pathway activity and estradiol mediated activation of rapid signaling cascades.
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