Pre-attentive, context-specific representation of fear memory in the auditory cortex of rat.
Pre-attentive, context-specific representation of fear memory in the auditory cortex of rat.
复制标题
DOI：
10.1371/journal.pone.0063655
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Takahashi H
中科院分区：
文献类型：
--
作者：
Funamizu A;Kanzaki R;Takahashi H
听觉皮层中的神经表征被自上而下的注意和自下而上的刺激属性快速调制，以改善给定背景下的感知。学习诱导的，前注意，地图可塑性也已研究在麻醉皮层，但是，很少有人注意到快速，上下文相关的调制。我们假设，特定情境学习导致听觉皮层的预注意调制，多重表征。在这里，我们研究了以上下文相关方式条件化的麻醉大鼠听觉皮质的地图可塑性，例如20 kHz音调的条件刺激（CS）和轻度电击的非条件刺激（US）仅在嘈杂的听觉环境下相关联，而不是在安静的情况下。条件反射后，虽然没有明显的可塑性，发现在tonotopic地图，音调诱发反应更抗噪声比预条件反射。然而，条件组显示出减少的激活传播到每个音调与噪音，但不是与沉默，与锐化的频率调谐。神经元的编码准确性指数表明，条件反射恶化的音调频率表征的准确性，在嘈杂的条件下，在关闭CS区域，但不是在CS区域，这表明，在一个特定的情况下，在CS的频率附近的任意音调更可能被感知为CS，其中CS与US相关。这些结果共同表明，学习诱导的可塑性在听觉皮层发生在一个上下文相关的方式。
Neural representation in the auditory cortex is rapidly modulated by both top-down attention and bottom-up stimulus properties, in order to improve perception in a given context. Learning-induced, pre-attentive, map plasticity has been also studied in the anesthetized cortex; however, little attention has been paid to rapid, context-dependent modulation. We hypothesize that context-specific learning leads to pre-attentively modulated, multiplex representation in the auditory cortex. Here, we investigate map plasticity in the auditory cortices of anesthetized rats conditioned in a context-dependent manner, such that a conditioned stimulus (CS) of a 20-kHz tone and an unconditioned stimulus (US) of a mild electrical shock were associated only under a noisy auditory context, but not in silence. After the conditioning, although no distinct plasticity was found in the tonotopic map, tone-evoked responses were more noise-resistive than pre-conditioning. Yet, the conditioned group showed a reduced spread of activation to each tone with noise, but not with silence, associated with a sharpening of frequency tuning. The encoding accuracy index of neurons showed that conditioning deteriorated the accuracy of tone-frequency representations in noisy condition at off-CS regions, but not at CS regions, suggesting that arbitrary tones around the frequency of the CS were more likely perceived as the CS in a specific context, where CS was associated with US. These results together demonstrate that learning-induced plasticity in the auditory cortex occurs in a context-dependent manner.
登录
查看更多内容
DOI：
10.1523/jneurosci.5249-08.2009
发表时间：
2009-03-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
David SV;Mesgarani N;Fritz JB;Shamma SA
通讯作者：
Shamma SA
影响因子：
5.3
作者：
Elhilali, M;Fritz, JB;Shamma, SA
通讯作者：
Shamma, SA
DOI：
10.1073/pnas.092278099
发表时间：
2002-07-23
影响因子：
11.1
作者：
Blake, DT;Strata, F;Merzenich, MM
通讯作者：
Merzenich, MM
影响因子：
2.5
作者：
Doron, NN;Ledoux, JE;Semple, MN
通讯作者：
Semple, MN
影响因子：
2.8
作者：
Eggermont, Jos J.
通讯作者：
Eggermont, Jos J.