Desynchronizing electrical and sensory coordinated reset neuromodulation.
Desynchronizing electrical and sensory coordinated reset neuromodulation.
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DOI：
10.3389/fnhum.2012.00058
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发表时间：
2012
影响因子：
2.9
通讯作者：
Tass PA
中科院分区：
文献类型：
--
作者：
Popovych OV;Tass PA
协调复位（CR）刺激是一种基于同步神经元集合的亚群及时协调相位复位的去同步刺激技术。它最初是为电深部脑刺激（DBS）计算开发的，以实现有效的去同步和去除病理同步和连接（抗引燃）。在这里，我们通过计算表明，通过兴奋性和抑制性自适应突触相互作用的spike和burst模型神经元的集合，可以通过直接电刺激或间接（突触介导的）兴奋性和抑制性刺激来实现神经元群体的相位重置以及去同步和反点燃。我们的研究结果与DBS以及以病理性神经元同步为特征的神经系统疾病的感觉刺激有关。根据所获得的结果，我们可以预期深部脑CR神经调节在深度电极附近的局部效应（通过直接刺激神经元体或刺激轴突末端实现）和非局部CR效应（通过刺激兴奋性或抑制性传出纤维实现）可能相似甚至相同。此外，我们的研究结果表明，有效的去同步和抗点燃甚至可以通过非侵入性的感觉CR神经调节来实现。我们在神经系统疾病的背景下讨论感觉CR神经调节的概念。
Coordinated reset (CR) stimulation is a desynchronizing stimulation technique based on timely coordinated phase resets of sub-populations of a synchronized neuronal ensemble. It has initially been computationally developed for electrical deep brain stimulation (DBS), to enable an effective desynchronization and unlearning of pathological synchrony and connectivity (anti-kindling). Here we computationally show for ensembles of spiking and bursting model neurons interacting via excitatory and inhibitory adaptive synapses that a phase reset of neuronal populations as well as a desynchronization and an anti-kindling can robustly be achieved by direct electrical stimulation or indirect (synaptically-mediated) excitatory and inhibitory stimulation. Our findings are relevant for DBS as well as for sensory stimulation in neurological disorders characterized by pathological neuronal synchrony. Based on the obtained results, we may expect that the local effects in the vicinity of a depth electrode (realized by direct stimulation of the neurons' somata or stimulation of axon terminals) and the non-local CR effects (realized by stimulation of excitatory or inhibitory efferent fibers) of deep brain CR neuromodulation may be similar or even identical. Furthermore, our results indicate that an effective desynchronization and anti-kindling can even be achieved by non-invasive, sensory CR neuromodulation. We discuss the concept of sensory CR neuromodulation in the context of neurological disorders.
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影响因子：
8.6
作者：
Benabid, AL;Benazzous, A;Pollak, P
通讯作者：
Pollak, P
DOI：
10.1209/0295-5075/23/5/011
发表时间：
1993-08-10
期刊：
EUROPHYSICS LETTERS
影响因子：
--
作者：
HANSEL, D;MATO, G;MEUNIER, C
通讯作者：
MEUNIER, C
影响因子：
16.2
作者：
Feldman, DE
通讯作者：
Feldman, DE
影响因子：
2.4
作者：
GOLOMB, D;RINZEL, J
通讯作者：
RINZEL, J
影响因子：
3.4
作者：
BEST, EN
通讯作者：
BEST, EN