Treatment of experimental autoimmune encephalomyelitis by codelivery of disease associated Peptide and dexamethasone in acetalated dextran microparticles.
Treatment of experimental autoimmune encephalomyelitis by codelivery of disease associated Peptide and dexamethasone in acetalated dextran microparticles.
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DOI：
10.1021/mp4005172
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发表时间：
2014-03-03
影响因子：
4.9
通讯作者：
Ainslie KM
中科院分区：
文献类型：
--
作者：
Peine KJ;Guerau-de-Arellano M;Lee P;Kanthamneni N;Severin M;Probst GD;Peng H;Yang Y;Vangundy Z;Papenfuss TL;Lovett-Racke AE;Bachelder EM;Ainslie KM
多发性硬化症（MS）是一种中枢神经系统自身免疫性脱髓鞘疾病，可导致运动功能丧失，部分原因被认为是抗原特异性T细胞免疫反应引起的慢性炎症。目前的治疗方法抑制免疫系统，没有抗原特异性，增加了癌症、慢性感染和其他长期副作用的风险。在这项研究中，我们通过将髓磷脂少突胶质细胞糖蛋白（MOG）的免疫优势肽与地塞米松（DXM）共包成醋酸化葡聚糖（Ac-DEX）微粒（DXM/MOG/MPs）并皮下给药，展示了实验性自身免疫性脑脊髓炎（EAE） （MS模型）的治疗方法。共囊微颗粒制剂（MOG 17.6 μg, DXM 8 μg）连续3次注射后，小鼠临床评分由3.4降至1.6。这一临床评分的变化明显大于磷酸盐缓冲盐水（PBS）、空MPs、游离DXM和MOG、DXM/MPs和MOG/MPs。此外，用DXM/MOG/MPs治疗可显著抑制治疗小鼠脾细胞中疾病相关细胞因子（如IL-17、GM-CSF）的表达。在这里，我们展示了一种有希望的治疗方法，使用基于聚合物的微粒输送平台治疗多发性硬化症。
Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system that can cause loss of motor function and is thought to result, in part, from chronic inflammation due to an antigen-specific T cell immune response. Current treatments suppress the immune system without antigen specificity, increasing the risks of cancer, chronic infection, and other long-term side effects. In this study, we show treatment of experimental autoimmune encephalomyelitis (EAE), a model of MS, by coencapsulating the immunodominant peptide of myelin oligodendrocyte glycoprotein (MOG) with dexamethasone (DXM) into acetalated dextran (Ac-DEX) microparticles (DXM/MOG/MPs) and administering the microparticles subcutaneously. The clinical score of the mice was reduced from 3.4 to 1.6 after 3 injections 3 days apart with the coencapsulated microparticulate formulation (MOG 17.6 μg and DXM 8 μg). This change in clinical score was significantly greater than observed with phosphate-buffered saline (PBS), empty MPs, free DXM and MOG, DXM/MPs, and MOG/MPs. Additionally, treatment with DXM/MOG/MPs significantly inhibited disease-associated cytokine (e.g., IL-17, GM-CSF) expression in splenocytes isolated in treated mice. Here we show a promising approach for the therapeutic treatment of MS using a polymer-based microparticle delivery platform.
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地塞米松的块共聚物纳米颗粒会诱导白血病细胞死亡并增强治疗功效：一种新的小儿纳米医学应用。
影响因子：
4.9
作者：
Krishnan V;Xu X;Barwe SP;Yang X;Czymmek K;Waldman SA;Mason RW;Jia X;Rajasekaran AK
通讯作者：
Rajasekaran AK
DOI：
10.1073/pnas.0901592106
发表时间：
2009-04-07
影响因子：
11.1
作者：
Broaders, Kyle E.;Cohen, Joel A.;Frechet, Jean M. J.
通讯作者：
Frechet, Jean M. J.
影响因子：
4.9
作者：
Bachelder EM;Beaudette TT;Broaders KE;Fréchet JM;Albrecht MT;Mateczun AJ;Ainslie KM;Pesce JT;Keane-Myers AM
通讯作者：
Keane-Myers AM
影响因子：
9.3
作者：
Fissolo N;Costa C;Nurtdinov RN;Bustamante MF;Llombart V;Mansilla MJ;Espejo C;Montalban X;Comabella M
通讯作者：
Comabella M
影响因子：
7
作者：
Chappert P;Schwartz RH
通讯作者：
Schwartz RH