The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration.
The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration.
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DOI：
10.1016/j.semcdb.2017.11.010
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发表时间：
2017-12
影响因子：
7.3
通讯作者：
Rudnicki MA
中科院分区：
文献类型：
--
作者：
Hernández-Hernández JM;García-González EG;Brun CE;Rudnicki MA
肌生成调节因子（Myf 5、MyoD、myogenin和MRF 4）是基本螺旋-环-螺旋转录因子家族的成员，其控制胚胎发生和出生后肌发生期间骨骼肌细胞的确定和分化。它们的时间和空间表达的动态以及它们的生物化学特性允许识别四个MRF之间的精确和层次关系。这种关系建立了肌源性谱系以及终末肌源性表型的维持。全基因组技术的应用为MRF如何激活肌肉基因表达提供了重要的新信息。联合应用功能基因组学技术沿着单细胞谱系追踪策略将使我们更深入地了解肌生成决定、细胞分化和肌肉再生的机制。
The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are members of the basic helix-loop-helix family of transcription factors that control the determination and differentiation of skeletal muscle cells during embryogenesis and postnatal myogenesis. The dynamics of their temporal and spatial expression as well as their biochemical properties have allowed the identification of a precise and hierarchical relationship between the four MRFs. This relationship establishes the myogenic lineage as well as the maintenance of the terminal myogenic phenotype. The application of genome-wide technologies has provided important new information as to how the MRFs function to activate muscle gene expression. Application of combined functional genomics technologies along with single cell lineage tracing strategies will allow a deeper understanding of the mechanisms mediating myogenic determination, cell differentiation and muscle regeneration.
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影响因子：
4.6
作者：
Grifone, R;Demignon, J;Maire, P
通讯作者：
Maire, P
影响因子：
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作者：
Deato, Maria Divina E.;Marr, Michael T.;Sottero, Theo;Inouye, Carla;Hu, Ping;Tjian, Robert
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Gerber, AN;Klesert, TR;Tapscott, SJ
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64.8
作者：
HASTY, P;BRADLEY, A;KLEIN, WH
通讯作者：
KLEIN, WH