Maternal Inositol Status and Neural Tube Defects: A Role for the Human Yolk Sac in Embryonic Inositol Delivery?
Maternal Inositol Status and Neural Tube Defects: A Role for the Human Yolk Sac in Embryonic Inositol Delivery?
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DOI：
10.1093/advances/nmaa100
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发表时间：
2021-02-01
期刊：
影响因子：
--
通讯作者：
Glazier JD
中科院分区：
文献类型：
--
作者：
D'Souza SW;Copp AJ;Greene NDE;Glazier JD
在妊娠围受孕期补充肌醇可以改善胎儿受神经管缺陷（NTD;例如，脊柱裂）。这在提供预防对叶酸无反应的NTD的方法方面可能特别重要。本文综述了肌醇的特性，并介绍了肌醇在啮齿动物研究中预防NTDs的作用，以及其在降低人类妊娠NTD风险方面的有效性。NTD风险的可能减少母体肌醇意味着功能和发育重要的母体-胚胎肌醇的相互关系，也表明胚胎摄取肌醇对胚胎发育至关重要。在人类妊娠的胚胎阶段，当神经管关闭时，建立活跃的肌醇细胞摄取机制可能是正常发育的重要决定因素。我们提请注意母胎肌醇浓度梯度和关系的产生，并概述了肌醇可能被交付到早期发育的人类胚胎的运输途径。这些考虑提供了新的见解的机制，可能支持肌醇的能力，赋予胚胎发育的好处。
Supplementation with myo-inositol during the periconceptional period of pregnancy may ameliorate the recurrence risk of having a fetus affected by a neural tube defect (NTD; e.g., spina bifida). This could be of particular importance in providing a means for preventing NTDs that are unresponsive to folic acid. This review highlights the characteristics of inositol and describes the role of myo-inositol in the prevention of NTDs in rodent studies and the evidence for its efficacy in reducing NTD risk in human pregnancy. The possible reduction in NTD risk by maternal myo-inositol implies functional and developmentally important maternal–embryonic inositol interrelationships and also suggests that embryonic uptake of myo-inositol is crucial for embryonic development. The establishment of active myo-inositol cellular uptake mechanisms in the embryonic stages of human pregnancy, when the neural tube is closing, is likely to be an important determinant of normal development. We draw attention to the generation of materno-fetal inositol concentration gradients and relationships, and outline a transport pathway by which myo-inositol may be delivered to the early developing human embryo. These considerations provide novel insights into the mechanisms that may underpin inositol's ability to confer embryonic developmental benefit.
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DOI：
10.1111/j.1471-0528.2008.01700.x
发表时间：
2008-05-01
影响因子：
5.8
作者：
Boyd, P. A.;DeVigan, C.;Dolk, H.
通讯作者：
Dolk, H.
DOI：
10.1016/j.bbalip.2014.11.008
发表时间：
2015-06
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Bridges D;Saltiel AR
通讯作者：
Saltiel AR
影响因子：
4
作者：
Burton GJ;Jauniaux E
通讯作者：
Jauniaux E
DOI：
10.1152/ajprenal.1995.268.6.f983
发表时间：
1995-06-01
期刊：
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL FLUID AND ELECTROLYTE PHYSIOLOGY
影响因子：
--
作者：
BURG, MB
通讯作者：
BURG, MB
影响因子：
4.8
作者：
Berry, GT;Wu, S;Greer, JJ
通讯作者：
Greer, JJ