Serum Calcium Concentration Is Inversely Associated With Radiographic Knee Osteoarthritis: A Cross-Sectional Study.
Serum Calcium Concentration Is Inversely Associated With Radiographic Knee Osteoarthritis: A Cross-Sectional Study.
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DOI：
10.1097/md.0000000000002838
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发表时间：
2016-02
期刊：
影响因子：
1.6
通讯作者：
Lei GH
中科院分区：
文献类型：
--
作者：
Li H;Zeng C;Wei J;Yang T;Gao SG;Li YS;Luo W;Xiao WF;Xiong YL;Lei GH
探讨血清钙（Ca）浓度与膝关节骨性关节炎（OA）的关系。本研究共纳入2855名受试者。采用偶氮胂ⅲ法检测血清钙浓度。膝关节炎的x线片定义为至少一侧发生相当于Kellgren-Lawrence 2级的变化。血清Ca浓度分为4个四分位数，分别为≤2.27、2.28-2.34、2.35-2.41和≥2.42 mmol/L。在调整了一系列潜在的混杂因素后，采用多变量logistic分析来检验血清钙与膝关节骨性关节炎的关系。对于血清钙浓度与x线膝关节炎之间关系的每一个四分位数，计算其95% CI的OR值，以最低值作为参考。在多变量模型和调整了年龄、性别和BMI因素的模型中，血清钙浓度与膝关节骨性关节炎呈负相关。与参考（第一）四分位数相比，第二、第三和第四个四分位数的血清钙浓度的x线片膝关节OA的多变量调整OR （95% CI）分别为1.05 （95% CI: 0.83-1.31）、1.01 （95% CI: 0.80-1.27）和0.79 （95% CI: 0.62-1.00）。观察到接近统计学显著（P = 0.06）的趋势。与此同时，与参考文献相比，第四个四分位数中膝关节骨性关节炎的相对几率降低了0.79倍。血清钙浓度与膝关节骨性关节炎的x线表现呈负相关。
To examine the relationship between serum calcium (Ca) concentration and radiographic knee osteoarthritis (OA). This study covered a total of 2855 subjects. The serum Ca concentration was detected by the Arsenazo III method. The radiographic OA of the knee was defined as changes equivalent to Kellgren–Lawrence grade 2 on 1 side at least. The serum Ca concentration was categorized into 4 quartiles, which are ≤2.27, 2.28–2.34, 2.35–2.41, and ≥2.42 mmol/L, respectively. The relationship between serum Ca and radiographic knee OA was examined using the multivariable logistic analysis after adjusting a series of potential confounding factors. For each quartile of the relationship between serum Ca concentration and radiographic knee OA, the OR with 95% CI was calculated, and the one with the lowest value was considered to be the reference. An inverse association existed between serum Ca concentration and radiographic OA of the knee in the multivariable model and the model where the factors of age, sex, and BMI were adjusted. The multivariable-adjusted OR (95% CI) for radiographic knee OA in the second, third, and fourth quartiles of serum Ca concentration were 1.05 (95% CI: 0.83–1.31), 1.01 (95% CI: 0.80–1.27), and 0.79 (95% CI: 0.62–1.00), respectively, in comparison with the reference (first) quartile. A trend approaching to statistical significant (P = 0.06) was observed. Meanwhile, the relative odds of radiographic OA of the knee were decreased by 0.79 times in the fourth quartile in comparison with the reference. There is likely to be an inverse association between serum Ca concentration and radiographic OA of the knee.
影响因子：
4.5
作者：
Patel VB;Vacek JL;Graves L;Bhattacharya RK
通讯作者：
Bhattacharya RK