The evolution of vascular changes in the spontaneously hypertensive rat.
The evolution of vascular changes in the spontaneously hypertensive rat.
复制标题
自发性高血压大鼠血管变化的演变。
DOI：
10.1007/bf02374474
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
C. Limas
中科院分区：
文献类型：
--
作者：
C. Limas;B. Westrum;C. Limas
对Aoki-Okamoto系自发性高血压大鼠（SHR）血管病变的发展进行了纵向研究。对5 ~ 48周龄的主动脉和肾内动脉血管进行光镜和电镜观察。在20周龄动物中评价了注射辣根过氧化物酶（HRP）的内皮渗透性。SHR和年龄匹配的血压正常对照组（Wistar-Kyoto品系）的血管之间的形态学差异在10周龄时首次发现，并随着时间的推移变得更加明显。血管病理学涉及内膜和中膜。在主动脉和外周动脉中均观察到中膜增厚，后者与管腔直径减小相关。这些中间变化可能有助于维持血压升高。内膜病变主要累及主动脉，其特征为内皮下空间扩张伴酸性粘多糖沉积。在扩张的内皮下，示踪剂HRP的积累增加，这表明示踪剂的渗透性和/或保留增强。在易患动脉粥样硬化的动物物种中，这些内膜变化可以作为高血压个体中动脉粥样硬化病变更高倾向的结构基础。在SHR中，尽管收缩压在约20周龄时稳定，但内膜和中膜病变继续进展，变得更加广泛和严重;这表明不仅高血压的严重程度，而且其持续时间是血管损伤程度的重要决定因素。
A longitudinal study on the development of vascular lesions was carried out in the spontaneously hypertensive rat (SHR) of the Aoki-Okamoto strain. The aorta and intrarenal arterial vessels were examined at different ages, from 5 to 48 weeks, by light and electron microscopy. Endothelial permeability to injected horseradish peroxidase (HRP) was evaluated in 20-week-old animals. Morphologic differences between vessels of SHRs and age-matched normotensive controls (Wistar-Kyoto strain) were first noted at 10 weeks of age and became more pronounced with time. Vascular pathology involved both intima and media. Medial thickening was seen in both aorta and peripheral arteries and, in the latter, was associated with decreased luminal diameters. These medial changes may contribute to the maintenance of the elevated blood pressure. Intimal lesions affected predominantly the aorta and were characterized by an expansion of the subendothelial space with deposition of acid mucopolysaccharides. There was increased accumulation of tracer HRP in the expanded subendothelium, which suggested enhanced permeability and/or retention of the tracer. In animal species susceptible to atherosclerosis, these intimal changes could serve as the structural basis for the higher propensity for atheromatous lesions in hypertensive individuals. In the SHR, despite stabilization of systolic blood pressure at about 20 weeks of age, both intimal and medial lesions continue to progress and become more extensive and severe; this suggests that not only the severity of hypertension but also its duration are significant determinants of the degree of vascular damage.
影响因子：
3.2
作者：
GRAHAM, RC;KARNOVSKY, MJ
通讯作者：
KARNOVSKY, MJ