Prospective study of infantile haemangiomas: incidence, clinical characteristics and association with placental anomalies.
Prospective study of infantile haemangiomas: incidence, clinical characteristics and association with placental anomalies.
复制标题
DOI：
10.1111/bjd.12804
复制
发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Friedlander SF
中科院分区：
文献类型：
--
作者：
Munden A;Butschek R;Tom WL;Marshall JS;Poeltler DM;Krohne SE;Alió AB;Ritter M;Friedlander DF;Catanzarite V;Mendoza A;Smith L;Friedlander M;Friedlander SF
婴儿血管瘤（IH）的病因和确切发病率尚不清楚。先前的研究已经注意到IH和胎盘组织共有的免疫组织化学和生物学特征。我们调查了胎盘异常与IH发展之间的可能联系，以及人口统计学特征和IH的其他危险因素。578名孕妇前瞻性入组，其后代随访9个月。进行胎盘评估，并收集所有母婴对的人口统计学数据。对594名婴儿进行了评估：在27名婴儿中确定了32个血管瘤（IH或先天性（CH）），IH的发生率为4.5%，CH为0.3%。在近35%的血管瘤相关妊娠中观察到胎盘异常，约为未受影响婴儿妊娠发生率的两倍。（p = 0.025）。IH的其他风险因素包括早产（p = 0.016）和低出生体重（p = 0.028）。所有的IH都出现在3个月大的时候，并且在9个月大的时候停止生长。大多数发生在树干上。值得注意的是，20%确定的IH本质上是流产/毛细血管扩张，小的局灶性病变在3个月龄后不会增殖。只有1例IH需要干预。这是美国第一项前瞻性研究，记录了从出生到婴儿早期的婴儿IH发病率。与胎盘异常的相关性具有统计学意义。总体发病率反映了先前的估计，但治疗需求低于先前报告的水平。
The etiology and exact incidence of infantile hemangiomas (IH) are unknown. Prior studies have noted immunohistochemical and biologic characteristics shared by IH and placental tissue. We investigated the possible association between placental anomalies and the development of IH, as well as the demographic characteristics and other risk factors for IH. 578 pregnant women were prospectively enrolled and their offspring followed for 9 months. Placental evaluations were performed and demographic data collected on all mother-infant pairs. 594 infants were evaluated: 32 hemangiomas (either IH or congenital (CH)) were identified in 27 infants, yielding an incidence of 4.5% for IH and 0.3% for CH. Placental anomalies were noted in almost 35% of hemangioma-related pregnancies, approximately twice the incidence noted in pregnancies with unaffected infants. (p = 0.025). Other risk factors for IH included prematurity (p = 0.016) and low birth weight (p = 0.028). All IH were present by 3 months of age, and cessation of growth had occurred in all by 9 months of age. Most occurred on the trunk. Of note, 20% of identified IH were abortive/telangiectatic in nature, small focal lesions that did not proliferate beyond 3 months of age. Only one IH required intervention. This is the first prospective American study to document the incidence of IH in infants followed from birth to early infancy. The association with placental anomalies was statistically significant. The overall incidence mirrors prior estimates, but the need for treatment was lower than previously reported.
登录
查看更多内容
影响因子：
1.5
作者：
Chen, Xiao Dong;Ma, Gang;Lin, Xiao Xi
通讯作者：
Lin, Xiao Xi
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
8
作者：
Haggstrom, Anita N.;Drolet, Beth A.;Frieden, Ilona J.
通讯作者：
Frieden, Ilona J.
影响因子：
1.5
作者：
Dickison, Philippa;Christou, Elizabeth;Wargon, Orli
通讯作者：
Wargon, Orli
影响因子：
15.9
作者：
Khan, Zia A.;Boscolo, Elisa;Bischoff, Joyce
通讯作者：
Bischoff, Joyce