Anticipatory pleasure for future rewards is attenuated in patients with schizophrenia but not in individuals with schizotypal traits
Anticipatory pleasure for future rewards is attenuated in patients with schizophrenia but not in individuals with schizotypal traits
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精神分裂症患者对未来奖励的预期快乐会减弱，但具有精神分裂特征的个体不会减弱
DOI：
10.1016/j.schres.2018.12.003
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发表时间：
2019-04
影响因子：
4.5
通讯作者：
Chan Raymond C K
中科院分区：
文献类型：
--
作者：
Yan Chao;Lui Simon S Y;Zou Lai quan;Wang Chuan yue;Zhou Fu chun;Cheung Eric F C;Shum David H K;Chan Raymond C K
在精神分裂症患者中经常观察到快感缺乏悖论。然而，特质和状态享乐能力分离的潜在机制尚不清楚。在本研究中，我们旨在重新审视精神分裂症（SCZ）患者和高分裂型（HS）个体的快感缺乏症，使用货币激励延迟（MID）任务来评估预期和圆满愉悦的不同维度。我们招募了44名SCZ患者，46名健康对照（HC）， 30名HS患者和35名低分裂型（LS）患者。修改后的MID任务被用来根据效价和唤醒评级来测量预期性和完满性愉悦。为了测量预期快乐的预测价值，参与者被要求在MID任务之前预测他们的享乐体验。对于SCZ患者，组主效应或 × 组奖励交互作用对获得奖励的满意程度或损失回避均无显著影响。不出所料，与HC相比，SCZ患者（尤其是男性患者）在预测和感觉维度上对未来奖励的愉悦感和兴奋感都较低。此外，男性患者报告的预期性和完满性负性比HC患者少。HS个体比LS个体对高奖励有更多的唤起经验。他们还报告并预测了更多对当前和未来经济损失的负面影响。此外，精神分裂型的消极维度预测了对未来奖励的低水平愉悦和唤醒，而积极维度预测了对未来奖励的增加唤醒体验。总之，精神分裂症的快感缺乏悖论可以部分地解释为预期愉悦和圆满愉悦之间的分离。
The anhedonia paradox is consistently observed in individuals with schizophrenia. However, the underlying mechanism of the dissociation between trait and state hedonic capacity remains unclear. In the present study, we aimed to re-examine anhedonia in patients with schizophrenia (SCZ) and individuals with high schizotypy (HS) using the Monetary Incentive Delay (MID) task to assess different dimensions of anticipatory and consummatory pleasure. We recruited 44 SCZ patients, 46 matched healthy controls (HC), 30 individuals with HS and 35 with low schizotypy (LS). The modified MID task was used to measure anticipatory and consummatory pleasure in terms of valence and arousal ratings. To measure the predictive value of anticipatory pleasure, participants were asked to predict their hedonic experience before the MID task. For SCZ patients, there was no significant Group main effect or Group × Prize interaction on consummatory pleasantness to reward received or loss avoidance. As expected, SCZ patients (particularly male patients) reported less pleasantness and arousal to future rewards in both the prediction and feeling dimensions compared with HC. Additionally, male patients reported less anticipatory and consummatory negativity than HC. Individuals with HS predicted more arousing experience to high-rewards than LS individuals. They also reported and predicted more negativity to in-the-moment and future monetary losses. Further, the negative dimension of schizotypy predicted low levels of pleasantness and arousal towards future rewards, but the positive dimension predicted increased arousing experience towards future rewards. In conclusion, the anhedonia paradox in schizophrenia could be partially accounted for by the dissociation between anticipatory and consummatory pleasure.
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影响因子：
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通讯作者：
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影响因子：
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影响因子：
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作者：
Chan, Raymond C. K.;Wang, Yi;Stone, William S.
通讯作者：
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影响因子：
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