The motivational valence of methamphetamine relates inversely to subsequent methamphetamine self-administration in female C57BL/6J mice.
The motivational valence of methamphetamine relates inversely to subsequent methamphetamine self-administration in female C57BL/6J mice.
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甲基苯丙胺的动机效价与雌性 C57BL/6J 小鼠随后自我施用甲基苯丙胺成反比。
DOI：
10.1016/j.bbr.2020.112959
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发表时间：
2021-02-01
影响因子：
2.7
通讯作者：
Szumlinski KK
中科院分区：
文献类型：
--
作者：
Shab G;Fultz EK;Page A;Coelho MA;Brewin LW;Stailey N;Brown CN;Bryant CD;Kippin TE;Szumlinski KK
理解成瘾脆弱性个体差异的机制需要开发经过验证的高通量筛选。在之前对雄性同基因C57 BL/6 J小鼠的大样本研究中，甲基苯丙胺（MA）诱导的位置调节的方向和幅度预测了获得口服MA自我给药的倾向，以及MA作为药物的功效。本研究探讨了这种预测关系是否也存在于女性。成年C57 BL/6 J雌性动物接受为期4天的MA位置调节模式（每日一次注射2 mg/kg），然后在递增的强化时间表下训练鼻子戳以递送20 mg/L MA溶液，然后进行剂量反应试验（5-400 mg/L MA）。与雄性相似，53%的雌性表现出条件性的位置偏好，而32%的小鼠是MA中性的，15%表现出条件性的位置厌恶。然而，与男性不同的是，在操作性条件反射程序下，位置条件反射表型并没有转移到MA强化的鼻子戳行为，400 mg/L MA摄入量与位置条件反射呈负相关。虽然迄今为止仅测定了一种MA调节剂量，但这些数据表明，性别不会显著改变C57 BL/6 J小鼠的比例，这些小鼠将MA的内感受性效应视为阳性，中性或厌恶。然而，性别差异似乎存在的动机效价的MA和随后的吸毒行为之间的预测关系;女性表现出MA服用行为和强化，尽管他们最初的感觉是积极的，中性的或消极的刺激性内感受性的影响。
Understanding the mechanisms underpinning individual variance in addiction vulnerability requires the development of validated, high-throughput screens. In a prior study of a large sample of male isogenic C57BL/6J mice, the direction and magnitude of methamphetamine (MA)-induced place-conditioning predicts the propensity to acquire oral MA self-administration, as well as the efficacy of MA to serve as a reinforcer.. The present study examined whether or not such a predictive relationship also exists in females. Adult C57BL/6J females underwent a 4-day MA place-conditioning paradigm (once daily injections of 2 mg/kg) and were then trained to nose-poke for delivery of a 20 mg/L MA solution under increasing schedules of reinforcement, followed by dose-response testing (5–400 mg/L MA). Akin to males, 53% of the females exhibited a conditioned place-preference, while 32% of the mice were MA-neutral and 15% exhibited a conditioned place-aversion. However, unlike males, the place-conditioning phenotype did not transfer to MA-reinforced nose-poking behavior under operant-conditioning procedures, with 400 mg/L MA intake being inversely correlated place-conditioning. While only one MA-conditioning dose has been assayed to date, these data indicate that sex does not significantly shift the proportion of C57BL/6J mice that perceive MA’s interoceptive effects as positive, neutral or aversive. However, a sex difference appears to exist regarding the predictive relationship between the motivational valence of MA and subsequent drug-taking behavior; females exhibit MA-taking behavior and reinforcement, despite their initial perception of the stimulant interoceptive effects as positive, neutral or negative.
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影响因子：
3.2
作者：
Ji, J.;McDermott, J. L.;Dluzen, D. E.
通讯作者：
Dluzen, D. E.
影响因子：
3.7
作者：
Bryant, Camron D.;Kole, Loren A.;Palmer, Abraham A.
通讯作者：
Palmer, Abraham A.
影响因子：
3.9
作者：
Hser, YI;Evans, E;Huang, YC
通讯作者：
Huang, YC
DOI：
10.1007/7854_2011_162
发表时间：
2013-01-01
期刊：
BEHAVIORAL NEUROBIOLOGY OF ALCOHOL ADDICTION
影响因子：
--
作者：
Crabbe, John C.;Kendler, Kenneth S.;Hitzemann, Robert J.
通讯作者：
Hitzemann, Robert J.
影响因子：
4.8
作者：
Banks, Matthew L.;Hutsell, Blake A.;Negus, S. Stevens
通讯作者：
Negus, S. Stevens