Effects of platelet-activating factor antagonist CV-3988 in preservation of heart and lung for transplantation.
Effects of platelet-activating factor antagonist CV-3988 in preservation of heart and lung for transplantation.
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血小板活化因子拮抗剂CV-3988对保存心脏和肺移植的影响。
DOI：
10.1016/0003-4975(91)91272-w
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
A. Poostizadeh
中科院分区：
文献类型：
--
作者：
A. Qayumi;W. Jamieson;A. Poostizadeh
心脏和肺的保存以供移植仍然是延长缺血间期的主要问题。本实验评价了高分子量去铁胺和一种血小板活化因子拮抗剂(CV-3988)对缺血再灌注组织的影响。在猪模型上，于缺血4小时45分钟后进行心肺移植。动物被分成三组。A组为无药物干预的对照组。B组给予大分子去铁胺50 mg/kg，C组给予血小板活化因子拮抗剂CV-3988 10 mg/kg。功能变量(心指数、卒中指数、肺水、氧分压和二氧化碳分压、肺泡-动脉梯度和肺泡-动脉比)结果显示，B组和C组的心肺功能优于对照组。使用血小板活化因子拮抗剂的C组心肺功能改变明显减轻(P<0.001)。研究表明，羟基自由基和血小板活化因子的形成在脑缺血再灌注损伤的发病机制中起重要作用。用大分子去铁胺抑制羟基自由基生成，用CV-3988灭活血小板活化因子，可明显减轻缺血再灌注损伤。
The preservation of heart and lung for transplantation remains a major concern in extended ischemic intervals. This experiment evaluated the effect of high molecular weight deferoxamine and a platelet-activating factor antagonist (CV-3988) in ischemic reperfused tissue. Heart-lung transplantation was performed in a swine model after 4 hours 45 minutes of ischemia. Animals were divided into three groups. Group A was a control without pharmacological intervention. In group B, high molecular weight deferoxamine, 50 mg/kg, was used, and in group C, platelet-activating factor antagonist CV-3988, 10 mg/kg, was used. The results of functional variables (cardiac index, stroke index, lung water, oxygen and carbon dioxide tensions, alveolar-arterial gradient, and alveolar-arterial ratio) demonstrated superior heart and lung function for groups B and C compared with the control group. These alterations of heart and lung function were significantly less (p< 0.001) in group C, in which the platelet-activating factor antagonist (CV-3988) was used. The study revealed that formation of hydroxyl radicals and platelet-activating factor play an important role in the pathogenesis of ischemia reperfusion injury. Prevention of hydroxyl radical formation with high molecular weight deferoxamine and inactivation of platelet-activating factor with CV-3988 reduce the ischemia-reperfusion injury significantly.
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DOI：
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DOI：
10.1164/arrd.1984.129.5.742
发表时间：
1984
期刊：
The American review of respiratory disease
影响因子：
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