Global prevalence and burden of meal-related abdominal pain.
Global prevalence and burden of meal-related abdominal pain.
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DOI：
10.1186/s12916-022-02259-7
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发表时间：
2022-02-17
期刊：
影响因子：
9.3
通讯作者：
Simrén M
中科院分区：
文献类型：
--
作者：
Colomier E;Melchior C;Algera JP;Hreinsson JP;Störsrud S;Törnblom H;Van Oudenhove L;Palsson OS;Bangdiwala SI;Sperber AD;Tack J;Simrén M
患有肠-脑相互作用障碍（DGBI）的患者报告膳食摄入与症状相关。有进餐相关症状的DGBI患者总体上可能有更严重的症状和更差的健康结果，但该亚组尚未得到很好的表征。我们的目的是描述全球范围内与进餐相关的腹痛的患病率，并描述这一亚组的特征。分析的数据来自罗马基金会全球流行病学研究的互联网调查部分，该研究在26个国家完成（n = 54，127）。成年受试者被问到他们是否有腹痛，以及这与饮食有关的频率。根据0%、10- 40%和≥50%的疼痛发作与进餐相关，将应答者分为“无”、“偶尔”和“频繁”进餐相关腹痛组。DGBI诊断，其他GI症状的频率，心理困扰，非GI躯体症状，生活质量和医疗保健利用进行了比较。混合线性和顺序回归用于评估心理困扰、非GI躯体症状、生活质量、其他GI症状和进餐相关腹痛之间的独立关联。总体而言，51.9%的受访者在过去3个月内报告腹痛，11.0%属于经常发生与进餐有关的腹痛的群体，其中包括更多的女性和年轻受试者。DGBI诊断更常见于频繁出现进餐相关腹痛的受试者，并且几种GI症状的频率与更频繁的进餐相关腹痛相关。更频繁地发生与进餐相关的腹痛也与更严重的心理困扰、非胃肠道躯体症状和更差的生活质量相关。与其他与膳食有关的腹痛组相比，与膳食有关的腹痛组经常因肠道问题咨询医生。报告频繁的进餐相关腹痛在地球仪中很常见，并与其他GI和非GI躯体症状、心理困扰、医疗保健利用和较差的生活质量相关。经常经历与进餐有关的腹痛的个体也更经常地满足DGBI的诊断标准。评估所有DGBI患者的进餐相关症状对改善和个性化症状管理至关重要。在线版本包含补充材料，可通过10.1186/s12916-022-02259-7获得。
Patients with disorders of gut-brain interaction (DGBI) report meal intake to be associated with symptoms. DGBI patients with meal-related symptoms may have more severe symptoms overall and worse health outcomes, but this subgroup has not been well characterized. We aimed to describe the global prevalence of meal-related abdominal pain and characterize this subgroup. The data analyzed originated from the Internet survey component of the population-based Rome Foundation Global Epidemiology Study, completed in 26 countries (n = 54,127). Adult subjects were asked whether they had abdominal pain and how often this was meal-related. Respondents were categorized into “no,” “occasional,” and “frequent” meal-related abdominal pain groups based on 0%, 10–40%, and ≥50% of the pain episodes being meal-related, respectively. DGBI diagnoses, frequency of other GI symptoms, psychological distress, non-GI somatic symptoms, quality of life, and healthcare utilization were compared between groups. Mixed linear and ordinal regression was used to assess independent associations between psychological distress, non-GI somatic symptoms, quality of life, other GI symptoms, and meal-related abdominal pain. Overall, 51.9% of the respondents reported abdominal pain in the last 3 months, and 11.0% belonged to the group with frequent meal-related abdominal pain, which included more females and younger subjects. DGBI diagnoses were more common in subjects with frequent meal-related abdominal pain, and the frequency of several GI symptoms was associated with having more frequent meal-related abdominal pain. Having meal-related abdominal pain more frequently was also associated with more severe psychological distress, non-GI somatic symptoms, and a poorer quality of life. The group with frequent meal-related abdominal pain also more often consulted a doctor for bowel problems compared to the other groups of meal-related abdominal pain. Reporting frequent meal-related abdominal pain is common across the globe and associated with other GI and non-GI somatic symptoms, psychological distress, healthcare utilization, and a poorer quality of life. Individuals who frequently experience meal-related abdominal pain also more frequently fulfill the diagnostic criteria for DGBI. Assessing meal-related symptoms in all DGBI patients could be of major importance to improve and individualize symptom management. The online version contains supplementary material available at 10.1186/s12916-022-02259-7.
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