Intestinal and plasma VEGF levels in cirrhosis: the role of portal pressure.
Intestinal and plasma VEGF levels in cirrhosis: the role of portal pressure.
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DOI：
10.1111/j.1582-4934.2011.01399.x
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发表时间：
2012-05
影响因子：
5.3
通讯作者：
Iwakiri Y
中科院分区：
文献类型：
--
作者：
Huang HC;Haq O;Utsumi T;Sethasine S;Abraldes JG;Groszmann RJ;Iwakiri Y
肠道 VEGF 水平升高被认为会加重门脉高压。肝硬化期间肠道 VEGF 水平升高的原因尚不清楚。本研究的目的是证明门静脉压力 (PP) 与纤维化/肝硬化不同阶段的肠道/血浆 VEGF 水平之间的关系。在该实验中，大鼠暴露于四氯化碳（CCl4）6、8和12周。在暴露结束时，三组大鼠分别表现出三个不同的病理阶段：非肝硬化、早期纤维化和肝硬化。对于这些大鼠及其年龄匹配的对照组，测量了 PP 和肠道/血浆 VEGF 水平。吸入 CCl4 12 周的大鼠出现门静脉高压（18.02 ± 1.07 mmHg），而暴露 6 周（7.26 ± 0.58 mmHg）和 8 周（8.55 ± 0.53 mmHg）的大鼠则没有。与对照组相比，暴露12周的大鼠肠道VEGF水平也增加了40%（P < 0.05），而暴露于CCl4吸入6周和8周的大鼠则没有增加40%。 PP与肠道VEGF水平呈显着正相关（r2=0.4，P<0.005）。与对照组 (8.5 pg/ml) 相比，吸入 CCl4 12 周的大鼠血浆 VEGF 水平显着升高 (63.7 pg/ml，P < 0.01)。然而，没有观察到 PP 和血浆 VEGF 水平之间存在相关性。结论是，门静脉压力在肝硬化发展过程中调节肠道 VEGF 水平。
Increased levels of intestinal VEGF are thought to worsen portal hypertension. The cause of the increase in the level of intestinal VEGF found during cirrhosis is not known. The aim of this study is to demonstrate a relationship between portal pressure (PP) and intestinal/ plasma VEGF levels in different stages of fibrosis/cirrhosis. In this experiment, rats were exposed to carbon tetrachloride (CCl4) for 6, 8 and 12 weeks. At the end of exposure, the three groups of rats exhibited three different stages of pathology: non-cirrhotic, early fibrotic and cirrhotic, respectively. For those rats and their age-matched controls, PP and intestinal/plasma VEGF levels were measured. Rats inhaling CCl4 for 12 weeks developed portal hypertension (18.02 ± 1.07 mmHg), while those exposed for 6 weeks (7.26 ± 0.58 mmHg) and for 8 weeks (8.55 ± 0.53 mmHg) did not. The rats exposed for 12 weeks also showed a 40% increase in the level of intestinal VEGF compared to the controls (P < 0.05), while those rats exposed to CCl4 inhalation for 6 and 8 weeks did not. There was a significant positive correlation between PP and intestinal VEGF levels (r2 = 0.4, P < 0.005). Plasma VEGF levels were significantly elevated in those rats exposed to 12 weeks of CCl4 inhalation (63.7 pg/ml, P < 0.01), compared to the controls (8.5 pg/ml). However, no correlation was observed between PP and plasma VEGF levels. It is concluded that portal pressure modulates intestinal VEGF levels during the development of cirrhosis.
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DOI：
10.3109/08977199109000278
发表时间：
1991-01-01
期刊：
Growth factors (Chur, Switzerland)
影响因子：
--
作者：
Ferrara, N;Winer, J;Burton, T
通讯作者：
Burton, T
影响因子：
13.5
作者：
Mejias, Marc;Garcia-Pras, Ester;Fernandez, Mercedes
通讯作者：
Fernandez, Mercedes
影响因子：
25.7
作者：
Reiberger, Thomas;Angermayr, Bernhard;Peck-Radosavjevic, Markus
通讯作者：
Peck-Radosavjevic, Markus
影响因子：
13.5
作者：
Fernandez, Mercedes;Mejias, Marc;Bosch, Jaime
通讯作者：
Bosch, Jaime
影响因子：
4.7
作者：
Gutierrez, LS;Suckow, M;Castellino, FJ
通讯作者：
Castellino, FJ