Neural Mechanisms of Motor Dysfunction in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.
Neural Mechanisms of Motor Dysfunction in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.
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DOI：
10.3233/adr-210065
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发表时间：
2022
影响因子：
3.2
通讯作者：
Duff, Kevin
中科院分区：
文献类型：
--
作者：
Koppelmans, Vincent;Silvester, Benjamin;Duff, Kevin
关键词：
尽管运动症状在轻度认知障碍（MCI）和阿尔茨海默病（AD）中普遍存在，但其潜在的神经机制尚未得到深入研究。本文综述了MCI和AD中运动缺陷的神经基础。我们检索了PubMed直到2021年8月，并确定了37篇关于MCI和AD中运动功能的神经影像学文章。根据样本量、对照样本的可获得性和研究人群的诊断定义来评估研究偏倚。大多数研究调查步态，表明步态较慢与海马体积较小和前额叶失活有关。在认知-运动双重任务中也观察到较少的前额叶激活，而在执行手挤压任务时观察到更多的小脑、扣带、楔叶、体感觉和梭状回脑区域激活。阿尔茨海默病患者皮层下白质损伤过多与帕金森症状、认知和运动双重任务中的较差表现以及较差的功能活动能力相关。步态和认知双重任务还与颞叶皮质厚度有关。大多数非步态运动测量仅在一项与神经测量相关的研究中报道。横断面设计、缺乏对照组、遗忘性和非遗忘性MCI混合、忽视性别差异和小样本量限制了一些研究的解释，这些需要在未来的研究中解决，以推动该领域的发展。
Despite the prevalence of motor symptoms in mild cognitive impairment (MCI) and Alzheimer’s disease (AD), their underlying neural mechanisms have not been thoroughly studied. This review summarizes the neural underpinnings of motor deficits in MCI and AD. We searched PubMed up until August of 2021 and identified 37 articles on neuroimaging of motor function in MCI and AD. Study bias was evaluated based on sample size, availability of control samples, and definition of the study population in terms of diagnosis. The majority of studies investigated gait, showing that slower gait was associated with smaller hippocampal volume and prefrontal deactivation. Less prefrontal activation was also observed during cognitive-motor dual tasking, while more activation in cerebellar, cingulate, cuneal, somatosensory, and fusiform brain regions was observed when performing a hand squeezing task. Excessive subcortical white matter lesions in AD were associated with more signs of parkinsonism, poorer performance during a cognitive and motor dual task, and poorer functional mobility. Gait and cognitive dual-tasking was furthermore associated with cortical thickness of temporal lobe regions. Most non-gait motor measures were only reported in one study in relation to neural measures. Cross-sectional designs, lack of control groups, mixing amnestic- and non-amnestic MCI, disregard of sex differences, and small sample sizes limited the interpretation of several studies, which needs to be addressed in future research to progress the field.
DOI：
10.1093/geronb/gbaa184
发表时间：
2021-01-18
期刊：
The journals of gerontology. Series B, Psychological sciences and social sciences
影响因子：
--
作者：
Ruitenberg MFL;Koppelmans V
通讯作者：
Koppelmans V