Early Childhood Neurodevelopmental Outcomes in Children with Prenatal Zika Virus Exposure: A Cohort Study in Puerto Rico.
Early Childhood Neurodevelopmental Outcomes in Children with Prenatal Zika Virus Exposure: A Cohort Study in Puerto Rico.
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DOI：
10.1016/j.jpeds.2022.05.016
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发表时间：
2022-08
影响因子：
5.1
通讯作者：
Rodriguez-Rabassa, Mary
中科院分区：
文献类型：
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作者：
Alvarado-Domenech, Luisa, I;Rivera-Amill, Vanessa;Appleton, Allison A.;Rosario-Villafane, Viviana;Repollet-Carrer, Irelis;Borges-Rodriguez, Marilyn;Perez-Rodriguez, Nicole M.;Olivieri-Ramos, Odette;Gonzalez, Marielly;Gonzalez-Montalvo, Carmen;Muniz-Forestier, Wilmarie;Vargas-Lasalle, Luzeida;Perez-Padilla, Janice;Paz-Bailey, Gabriela;Rodriguez-Rabassa, Mary
描述从出生到36个月暴露于寨卡病毒的儿童的人体测量、感觉和神经发育结果。研究队列包括2016-2017年确诊和可能感染寨卡病毒的母亲所生的114名儿童。2017年5月至2020年2月参加研究访视的儿童接受了身体/神经系统、感觉检查，并使用贝利婴幼儿发育量表第三版（BSID-III）和年龄和阶段量表第三版（ASQ-3）进行神经发育评估。114名儿童中有3名（2.6%）在出生时患有小头畸形（头围z评分≤-2），35名儿童中有19名（54.3%）在视网膜图像中有后眼异常，109名儿童中有11名（10.1%）在脑超声中有非特异性发现。107名儿童中有3名（2.8%）在出生时未通过听力筛查。在这些有随访数据的儿童中，97名儿童中有17名（17.5%）未能通过与年龄相适应的视力筛查。BSID-III在至少三分之一的儿童中确定了至少一个领域的发育迟缓，其中语言领域的患病率较高。ASQ-3筛查阳性延迟在24或36个月左右达到峰值，一些领域在年龄较大时显示出下降。观察到BSID-III和ASQ-3评分之间的相关性，代表24和36个月时的专业和父母观点（r = 0.32-0.78; P <0.05）。儿童早期神经发育后遗症的存在表明，长期损害的识别仍然是实现最佳儿童发展的关键。长期随访突出了语言领域的脆弱性，这可能会受到早期干预的影响，促进受影响儿童的认知发展和入学准备。
To describe anthropometric, sensory, and neurodevelopmental outcomes of children who were Zika virus–exposed from birth to 36 months. The study cohort included 114 children born to mothers with confirmed and probable Zika virus pregnancy infection in 2016–2017. Children attending study visits from May 2017 through February 2020 underwent physical/neurologic, sensory examinations, and neurodevelopmental assessments with the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III) and Ages and Stages Questionnaires, Third Edition (ASQ-3). Three of the 114 children (2.6%) had microcephaly (z-score for head circumference ≤ −2) at birth, 19 of 35 (54.3%) had posterior eye abnormalities in retinal images, and 11 of 109 (10.1%) had nonspecific findings on brain ultrasound. Three of 107 children (2.8%) failed hearing screening at birth. Of those children with follow-up data, 17 of 97 (17.5%) failed age-appropriate vision screening. The BSID-III identified developmental delay in at least 1 domain in at least one-third of children, with higher prevalence in the language domain. ASQ-3 screen positive delay peaked at around 24 or 36 months, with some domains showing a decrease at older ages. Correlations among BSID-III and ASQ-3 scores were observed, representing professional and parental perspectives at 24 and 36 months (r = 0.32-0.78; P < .05). The presence of neurodevelopmental sequelae in early childhood suggests that identification of long-term impairment remains critical to attaining optimal child development. Long-term follow-up highlights vulnerability in the language domain, which likely could be influenced by early intervention, promoting cognitive development and school readiness in exposed children.
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DOI：
10.1016/s0140-6736(16)31389-7
发表时间：
2017-01-07
期刊：
Lancet (London, England)
影响因子：
--
作者：
Black MM;Walker SP;Fernald LCH;Andersen CT;DiGirolamo AM;Lu C;McCoy DC;Fink G;Shawar YR;Shiffman J;Devercelli AE;Wodon QT;Vargas-Barón E;Grantham-McGregor S;Lancet Early Childhood Development Series Steering Committee
通讯作者：
Lancet Early Childhood Development Series Steering Committee
影响因子：
26.1
作者：
Honein MA;Jamieson DJ
通讯作者：
Jamieson DJ
DOI：
10.1056/nejmoa1602412
发表时间：
2016-12-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brasil P;Pereira JP Jr;Moreira ME;Ribeiro Nogueira RM;Damasceno L;Wakimoto M;Rabello RS;Valderramos SG;Halai UA;Salles TS;Zin AA;Horovitz D;Daltro P;Boechat M;Raja Gabaglia C;Carvalho de Sequeira P;Pilotto JH;Medialdea-Carrera R;Cotrim da Cunha D;Abreu de Carvalho LM;Pone M;Machado Siqueira A;Calvet GA;Rodrigues Baião AE;Neves ES;Nassar de Carvalho PR;Hasue RH;Marschik PB;Einspieler C;Janzen C;Cherry JD;Bispo de Filippis AM;Nielsen-Saines K
通讯作者：
Nielsen-Saines K
影响因子：
3.5
作者：
Aragao, M. F. V. V.;Holanda, A. C.;Costello, A.
通讯作者：
Costello, A.
影响因子：
120.7
作者：
Honein, Margaret A.;Dawson, April L.;Jamieson, Denise J.
通讯作者：
Jamieson, Denise J.