The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus
The Functional Influence of Burst and Tonic Firing Mode on Synaptic Interactions in the Thalamus
复制标题
爆发和强直射击模式对丘脑突触相互作用的功能影响
DOI：
10.1523/jneurosci.18-22-09500.1998
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
D. McCormick
中科院分区：
文献类型：
--
作者：
Uhnoh Kim;D. McCormick
Thalamocortical and perigeniculate (PGN) neurons can generate action potentials either as Ca2+ spike–mediated high-frequency bursts or as tonic trains. Using dual intracellular recordings in vitro in monosynaptically connected pairs of PGN and dorsal lateral geniculate nucleus (LGNd) neurons, we found that the functional effect of synaptic transmission between these cell types was strongly influenced by the membrane potential and hence the firing mode of both the pre- and postsynaptic neurons. Activation of single action potentials or low-frequency spike trains in PGN or thalamocortical neurons resulted in the generation of PSPs that were 0.5–2.0 mV in amplitude. In contrast, the generation of Ca2+ spike-mediated bursts of action potentials in the presynaptic cell increased these PSPs to an average of 4.4 mV for the IPSP and 3.0 mV for the EPSP barrage, because of temporal summation and/or facilitation. If the postsynaptic neuron was at a resting membrane potential (e.g., −65 mV), these PSP barrages could result in the activation of a low-threshold Ca2+ spike and burst of action potentials. These results demonstrate that the burst firing mode of action potential generation is a particularly effective means by which perigeniculate and thalamocortical neurons may influence one another. We propose that the activation of burst discharges in these cell types is essential for the generation of some forms of synchronized rhythmic oscillations of sleep and of epileptic seizures.
登录
查看更多内容
猫膝状 W 细胞的形态和生理特性：与 X 和 Y 细胞的比较。
影响因子：
2.5
作者：
Stanford,LR;Friedlander,MJ;Sherman,SM
通讯作者：
Sherman,SM
急性分离海马神经元中 GABA 激活电流衰减的全细胞电压钳研究。
影响因子：
2.5
作者：
Huguenard,JR;Alger,BE
通讯作者：
Alger,BE
影响因子：
2.5
作者：
MCCARLEY, RW;BENOIT, O;BARRIONUEVO, G
通讯作者：
BARRIONUEVO, G
猫外侧膝状核主细胞抑制途径的突触组织。
影响因子：
2.9
作者：
Lindström,S
通讯作者：
Lindström,S
钙和递质释放。
DOI：
10.1016/0928-4257(93)90021-k
发表时间：
1993
期刊：
Journal of physiology, Paris
影响因子：
--
作者：
Zucker,RS
通讯作者：
Zucker,RS