Imaging of apoptosis in the heart with nanoparticle technology.
Imaging of apoptosis in the heart with nanoparticle technology.
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DOI：
10.1002/wnan.115
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发表时间：
2011-01
影响因子：
8.6
通讯作者：
Sosnovik, David E.
中科院分区：
文献类型：
--
作者：
Chen, Howard H.;Josephson, Lee;Sosnovik, David E.
Apoptosis plays an important role in the loss of cardiomyocytes in both ischemic injury and heart failure. Pioneering work with single photon emission computed tomography imaging of 99Tc-annexin showed that cell death in the heart could be imaged in vivo. Over the last 5 years a significant amount of experience with annexin-labeled magnetic nanoparticles, principally AnxCLIO-Cy5.5, has also been gained. Here, we review the experience with AnxCLIO-Cy5.5 in the heart and compare this experience to that of earlier studies with 99Tc-annexin. The imaging of apoptosis with AnxCLIO-Cy5.5 provides valuable insights not only into molecular imaging in the heart but, more broadly, into the use of nanoparticle technology for molecular imaging in general.
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影响因子：
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Krishnan, Anant S.;Neves, Andre A.;Brindle, Kevin M.
通讯作者：
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Strauss, HW
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ENGLER, RL
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158.5
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Weissleder, R
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通讯作者：
Sosnovik, David E.