Immunomodulatory Effects of IFNα on T and NK Cells in Chronic Myeloid Leukemia Patients in Deep Molecular Response Preparing for Treatment Discontinuation.
Immunomodulatory Effects of IFNα on T and NK Cells in Chronic Myeloid Leukemia Patients in Deep Molecular Response Preparing for Treatment Discontinuation.
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IFNα对深层分子反应中慢性髓样白血病患者T和NK细胞的免疫调节作用为治疗中断准备。
DOI：
10.3390/jcm11195594
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发表时间：
2022-09-23
影响因子：
3.9
通讯作者：
Foa, Robin
中科院分区：
文献类型：
--
作者：
Puzzolo, Maria Cristina;Breccia, Massimo;Mariglia, Paola;Colafigli, Gioia;Pepe, Sara;Scalzulli, Emilia;Mariggio, Elena;Latagliata, Roberto;Guarini, Anna;Foa, Robin
A deep and stable molecular response (DMR) is a prerequisite for a successful treatment-free remission (TFR) in chronic myeloid leukemia (CML). In order to better identify and analyze potential candidates of successful TFR, we examined the phenotypic and functional host immune compartment in DMR patients who had received TKI treatment only (TKI-only) or had been previously treated with interferon-alpha (IFNα + TKI) or had received IFNα treatment only (IFNα-only). The T/NK-cell subset distribution, NK- and T-cell cytokine production, activation and maturation markers were measured in 44 patients in DMR treated with IFNα only (9), with IFNα + TKI (11) and with TKI-only (24). IFNα + TKI and TKI-only groups were eligible to TKI discontinuation according to the NCCN and ESMO guidelines (stable MR4 for more than two years). In IFNα-treated patients, we documented an increased number of lymphocytes capable of producing IFNγ and TNFα compared to the TKI-only group. In INFα + TKI patients, the percentage of NKG2C expression and its mean fluorescence intensity were significantly higher compared to the TKI-only group and to the INFα-only group in the CD56dim/CD16+ NK cell subsets (INFα + TKI vs. TKI-only p = 0.041, p = 0.037; INFα + TKI vs. INFα-only p = 0.03, p = 0.033, respectively). Furthermore, in INFα-only treated patients, we observed an increase of NKp46 MFI in the CD56bright/CD16- NK cell subset that becomes significant compared to the INFα + TKI group (p = 0.008). Our data indicate that a previous exposure to IFNα substantially and persistently modified the immune system of CML patients in memory T lymphocytes, differentiated NKG2C+ “long-lived” NK cells responses, even years after the last IFNα contact.
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影响因子：
9.2
作者：
Marcus, Assaf;Raulet, David H.
通讯作者：
Raulet, David H.
影响因子：
7.3
作者：
Hughes A;Yong ASM
通讯作者：
Yong ASM
影响因子：
50.5
作者：
Hochhaus, A.;Saussele, S.;Buske, C.
通讯作者：
Buske, C.
影响因子：
--
作者：
Breccia M;Molica M;Colafigli G;Massaro F;Quattrocchi L;Latagliata R;Mancini M;Diverio D;Guarini A;Alimena G;Foà R
通讯作者：
Foà R
影响因子：
20.3
作者：
KOLB, HJ;SCHATTENBERG, A;ANSARI, H
通讯作者：
ANSARI, H