Evidence for natural killer cell memory.
Evidence for natural killer cell memory.
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DOI：
10.1016/j.cub.2013.07.015
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发表时间：
2013-09-09
期刊：
影响因子：
9.2
通讯作者：
Raulet, David H.
中科院分区：
文献类型：
--
作者：
Marcus, Assaf;Raulet, David H.
Natural killer (NK) cells are generally considered part of the innate immune system. However, over the past few years, evidence has accumulated suggesting that NK cells have certain features characteristic of the adaptive immune system. NK cells reportedly respond in an antigen-specific manner to a variety of small molecules and certain viruses, and mediate enhanced responses to these antigens upon re-challenge. In infections with mouse cytomegalovirus (MCMV), MCMV-specific NK cells undergo clonal expansion, and display increased effector function after the resolution of the infection. In addition, inflammatory conditions resulting from exposure to certain cytokines seem to cause prolonged effector function in NK cells in an antigen non-specific fashion. Taken together, these studies reveal new aspects of NK biology, and suggest that NK cells, like T and B cells, may carry out memory responses, and may also exhibit greater capacity to distinguish antigens than was previously recognized.
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影响因子：
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作者：
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DOI：
10.1084/jem.191.1.129
发表时间：
2000-01-03
期刊：
The Journal of experimental medicine
影响因子：
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发表时间：
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期刊：
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DOI：
10.1126/science.1198687
发表时间：
2011-01-07
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Vivier E;Raulet DH;Moretta A;Caligiuri MA;Zitvogel L;Lanier LL;Yokoyama WM;Ugolini S
通讯作者：
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作者：
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