Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states.
Phase-amplitude coupling between infraslow and high-frequency activities well discriminates between the preictal and interictal states.
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DOI：
10.1038/s41598-021-96479-1
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发表时间：
2021-08-31
影响因子：
4.6
通讯作者：
Hirata M
中科院分区：
文献类型：
--
作者：
Hashimoto H;Khoo HM;Yanagisawa T;Tani N;Oshino S;Kishima H;Hirata M
低频活动(ISA)和高频活动(HFA)是研究癫痫发作的关键生物标志物。我们的目的是阐明癫痫发作前后ISA和HFA的关系。我们招募了7名接受了颅内电极放置的抗药性局灶性癫痫患者。我们比较分析了发作间期、发作前和发作前的发作起始区(SOZ)和非SOZ区(NSOZ)的ISA、HFA和ISA-HFA的相位-幅度耦合(PAC)。我们记录了15次癫痫发作。发作期HFA和ISA均大于发作间期和发作前。在惊厥过程中，SOZ的HFA和ISA大于nSOZ，且出现的时间早于nSOZ。发作前SOZ的ISA-HFA PAC大于发作间期，发作前约87天左右，SOZ的ISA-HFA PAC开始增加。接受者-操作特征曲线显示，SOZ的ISA-HFA PAC在发作前和发作间期表现出最高的辨别性能，曲线下面积为0.926。这项研究证明了新的见解，即ISA-HFA PAC在癫痫发作之前增加。我们的研究结果表明，ISA-HFA PAC可作为区分发作前和发作间期状态的有用生物标志物。
Infraslow activity (ISA) and high-frequency activity (HFA) are key biomarkers for studying epileptic seizures. We aimed to elucidate the relationship between ISA and HFA around seizure onset. We enrolled seven patients with drug-resistant focal epilepsy who underwent intracranial electrode placement. We comparatively analyzed the ISA, HFA, and ISA-HFA phase-amplitude coupling (PAC) in the seizure onset zone (SOZ) or non-SOZ (nSOZ) in the interictal, preictal, and ictal states. We recorded 15 seizures. HFA and ISA were larger in the ictal states than in the interictal or preictal state. During seizures, the HFA and ISA of the SOZ were larger and occurred earlier than those of nSOZ. In the preictal state, the ISA-HFA PAC of the SOZ was larger than that of the interictal state, and it began increasing at approximately 87 s before the seizure onset. The receiver-operating characteristic curve revealed that the ISA-HFA PAC of the SOZ showed the highest discrimination performance in the preictal and interictal states, with an area under the curve of 0.926. This study demonstrated the novel insight that ISA-HFA PAC increases before the onset of seizures. Our findings indicate that ISA-HFA PAC could be a useful biomarker for discriminating between the preictal and interictal states.
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影响因子：
5.8
作者：
Hashimoto H;Takahashi K;Kameda S;Yoshida F;Maezawa H;Oshino S;Tani N;Khoo HM;Yanagisawa T;Yoshimine T;Kishima H;Hirata M
通讯作者：
Hirata M
影响因子：
5.3
作者：
Cimbalnik J;Brinkmann B;Kremen V;Jurak P;Berry B;Gompel JV;Stead M;Worrell G
通讯作者：
Worrell G
影响因子：
5.6
作者：
Ikeda, A;Terada, K;Shibasaki, H
通讯作者：
Shibasaki, H
影响因子：
14.5
作者：
Ikeda, A;Taki, W;Shibasaki, H
通讯作者：
Shibasaki, H
影响因子：
11.2
作者：
Frauscher, Birgit;von Ellenrieder, Nicolas;Gotman, Jean
通讯作者：
Gotman, Jean