An integrated fluid-structure interaction and thrombosis model for type B aortic dissection.
An integrated fluid-structure interaction and thrombosis model for type B aortic dissection.
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DOI：
10.1007/s10237-021-01534-5
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发表时间：
2022-03
影响因子：
3.5
通讯作者：
Lim E
中科院分区：
文献类型：
--
作者：
Chong MY;Gu B;Armour CH;Dokos S;Ong ZC;Xu XY;Lim E
B型主动脉夹层的假腔血栓形成（FLT）与夹层的进展和治疗结果有关。现有的计算模型大多假设刚性壁面行为，忽略了襟翼运动对FL内流动和血栓形成的影响。在本研究中，我们将完全耦合的流固相互作用（FSI）方法与由一系列对流扩散反应方程描述的剪切驱动血栓形成模型相结合。集成的fsi -血栓模型已应用于理想化的解剖几何，以研究血管壁运动与血栓生长之间的相互作用。仿真结果表明，壁面顺应性和襟翼运动会影响FLT的发展。刚性模型和FSI模型之间的主要区别在于，剧烈的襟翼运动导致的撕裂附近的漩涡持续发展，达到4.45 mm。在FSI模型中，皮瓣诱导的撕裂周围的高剪切应力和剪切速率有助于将活化的血小板进一步运输到邻近区域，从而加速血栓形成。通过增加皮瓣的杨氏模量来降低皮瓣的活动性可以减缓血栓的生长。与刚性模型相比，使用具有相对可移动皮瓣的fsi -血栓模型预测的血栓体积要大25%。此外，我们的fsi -血栓形成模型可以捕捉到血栓生长对流场的逐渐影响，导致血流阻塞，血液粘度增加和皮瓣运动减少。该模型考虑了内膜皮瓣和血管壁运动的影响，更接近于模拟主动脉夹层中血栓的真实生长。
False lumen thrombosis (FLT) in type B aortic dissection has been associated with the progression of dissection and treatment outcome. Existing computational models mostly assume rigid wall behavior which ignores the effect of flap motion on flow and thrombus formation within the FL. In this study, we have combined a fully coupled fluid–structure interaction (FSI) approach with a shear-driven thrombosis model described by a series of convection–diffusion reaction equations. The integrated FSI-thrombosis model has been applied to an idealized dissection geometry to investigate the interaction between vessel wall motion and growing thrombus. Our simulation results show that wall compliance and flap motion can influence the progression of FLT. The main difference between the rigid and FSI models is the continuous development of vortices near the tears caused by drastic flap motion up to 4.45 mm. Flap-induced high shear stress and shear rates around tears help to transport activated platelets further to the neighboring region, thus speeding up thrombus formation during the accelerated phase in the FSI models. Reducing flap mobility by increasing the Young’s modulus of the flap slows down the thrombus growth. Compared to the rigid model, the predicted thrombus volume is 25% larger using the FSI-thrombosis model with a relatively mobile flap. Furthermore, our FSI-thrombosis model can capture the gradual effect of thrombus growth on the flow field, leading to flow obstruction in the FL, increased blood viscosity and reduced flap motion. This model is a step closer toward simulating realistic thrombus growth in aortic dissection, by taking into account the effect of intimal flap and vessel wall motion.
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B 型主动脉夹层患者特异性研究：真假腔血液交换的评估
影响因子：
3.9
作者：
Chen D;Müller-Eschner M;von Tengg-Kobligk H;Barber D;Böckler D;Hose R;Ventikos Y
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3.7
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3.5
作者：
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通讯作者：
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DOI：
10.1016/j.ejvs.2016.07.006
发表时间：
2016-11-01
影响因子：
5.7
作者：
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通讯作者：
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