Exosomes Highlight Future Directions in the Treatment of Acute Kidney Injury.
Exosomes Highlight Future Directions in the Treatment of Acute Kidney Injury.
复制标题
外泌体强调急性肾损伤治疗的未来方向。
DOI：
10.3390/ijms242115568
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发表时间：
2023-10-25
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
急性肾损伤（阿基）是一种严重的健康问题，与高发病率和死亡率相关。目前缺乏具体的治疗策略。本文综述了来自不同细胞来源的外泌体在阿基中的作用机制，包括红细胞、巨噬细胞、单核细胞、间充质干细胞和肾小管细胞。我们还研究了各种外泌体内容物（如miRNA、lncRNA、circRNA、mRNA和蛋白质）在促进肾小管细胞再生和血管生成、调节自噬、抑制炎症反应和氧化应激以及预防纤维化以促进阿基修复中的作用。此外，我们强调了巨噬细胞和肾小管细胞之间通过外泌体的相互作用，这有助于阿基的进展。此外，外泌体及其内容物显示出作为诊断阿基的潜在生物标志物的前景。外泌体的工程化通过增强分离和富集、靶向递送至损伤的肾组织以及并入用于临床使用的小分子修饰来提高其临床潜力。然而，需要进一步的研究来更好地了解外泌体作用的具体机制，它们向肾小管细胞的递送途径，以及多组学研究在研究阿基中的应用。
Acute kidney injury (AKI) is a severe health problem associated with high morbidity and mortality rates. It currently lacks specific therapeutic strategies. This review focuses on the mechanisms underlying the actions of exosomes derived from different cell sources, including red blood cells, macrophages, monocytes, mesenchymal stem cells, and renal tubular cells, in AKI. We also investigate the effects of various exosome contents (such as miRNA, lncRNA, circRNA, mRNA, and proteins) in promoting renal tubular cell regeneration and angiogenesis, regulating autophagy, suppressing inflammatory responses and oxidative stress, and preventing fibrosis to facilitate AKI repair. Moreover, we highlight the interactions between macrophages and renal tubular cells through exosomes, which contribute to the progression of AKI. Additionally, exosomes and their contents show promise as potential biomarkers for diagnosing AKI. The engineering of exosomes has improved their clinical potential by enhancing isolation and enrichment, target delivery to injured renal tissues, and incorporating small molecular modifications for clinical use. However, further research is needed to better understand the specific mechanisms underlying exosome actions, their delivery pathways to renal tubular cells, and the application of multi-omics research in studying AKI.
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影响因子：
3.7
作者：
Dominguez JM 2nd;Dominguez JH;Xie D;Kelly KJ
通讯作者：
Kelly KJ
影响因子：
13.6
作者：
Collino, Federica;Bruno, Stefania;Camussi, Giovanni
通讯作者：
Camussi, Giovanni
影响因子：
5.6
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通讯作者：
On Behalf Of The Direct Investigators
影响因子：
48
作者：
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通讯作者：
Liu, Fei
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作者：
Cao, Jingyuan;Wang, Bin;Liu, Bicheng
通讯作者：
Liu, Bicheng