Association of MTHFR C677T and A1298C Polymorphisms with Susceptibility to Chronic Lymphocytic Leukemia: A Systematic Review and Meta-Analysis.
Association of MTHFR C677T and A1298C Polymorphisms with Susceptibility to Chronic Lymphocytic Leukemia: A Systematic Review and Meta-Analysis.
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DOI：
10.18502/ijph.v50i1.5074
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发表时间：
2021-01
影响因子：
1.4
通讯作者：
Hajifathali A
中科院分区：
文献类型：
--
作者：
Raoufi A;Rahimi Kelarijani B;Ahadi HR;Hassani Derakhshandeh B;Nooroollahzadeh Z;Hajifathali A
亚甲基四氢叶酸还原酶（MTHFR）基因多态性与慢性淋巴细胞白血病（CLL）发病风险之间的关系尚不清楚，虽然有关于MTHFR C677 T和A1298 C多态性与CLL发病相关的报道，但也有其他报道指出MTHFR基因多态性与CLL发病相关。因此，我们在此进行了这项荟萃分析，以明确MTHFR多态性与CLL风险的关联，从开始到2020年8月，通过PubMed，Scopus和Embase进行了全面检索。计算了5种可能的遗传模型的比值比（OR）及其相应的95%置信区间（CI）。使用Cochran Q检验和I2统计量评价杂散性。共有1290例病例和1887名对照的C677 T多态性和1117例病例和1256名对照的A1298 C多态性被纳入我们的分析。MTHFR基因C677 T和A1298 C多态性与CLL的发病风险相关（OR = 1.12，95%CI = 1.01-1.25），而MTHFR基因C677 T多态性与CLL的发病风险无关。在等位基因模型下，MTHFR基因A1298 C多态性可能与CLL的发病风险相关，而与MTHFR基因C677 T多态性无关。然而，MTHFR基因多态性与CLL的发病风险之间的关系还需要进一步的研究，如年龄、性别、种族、基因间的相互作用以及环境条件等。
The relation between methylenetetrahydrofolate reductase)MTHFR(polymorphisms and the risk of developing Chronic lymphocytic leukemia (CLL) is not still clear, while there are reports about the association of MTHFR C677T and A1298C polymorphisms with developing CLL, there are other reports that rolled out the association of MTHFR polymorphisms with developing CLL. Therefore herein we carried out this meta-analysis to clear the association of MTHFR polymorphisms with the risk of CLL, A comprehensive search was performed through PubMed, Scopus and Embase from inception to Aug 2020. Odds ratios (OR) with their corresponding 95% confidence intervals (CI) for five possible genetic models were calculated. Heterogeneity was evaluated using the Cochran Q test and the I2 statistic. Totals of 1290 cases and 1887 controls for the C677T polymorphism and 1117 cases and 1256 controls for the A1298C polymorphism were included in our analysis. Analyzing the MTHFR C677T and A1298C polymorphisms genotypes showed an association between MTHFR polymorphism at A1298C under Allelic model and the risk of CLL (OR = 1.12, 95% CI = 1.01–1.25), however there was no association between MTHFR polymorphism at MTHFR C677T and risk of CLL. The risk of developing CLL might be associated with MTHFR polymorphism at A1298C under allelic model and not associated with MTHFR polymorphisms at C677T, However, further studies considering other factors such as age, gender, ethnicity, gene-gene interaction and environmental condition are needed to clear the true association of MTHFR polymorphisms with CLL.
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影响因子：
7
作者：
Huedo-Medina, Tania B.;Sanchez-Meca, Julio;Botella, Juan
通讯作者：
Botella, Juan
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Nasedkina, Tatyana V.
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通讯作者：
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Santella, RM