The association between MTHFR polymorphism and cervical cancer.
The association between MTHFR polymorphism and cervical cancer.
复制标题
DOI：
10.1038/s41598-018-25726-9
复制
发表时间：
2018-05-08
影响因子：
4.6
通讯作者：
He YX
中科院分区：
文献类型：
--
作者：
Gong JM;Shen Y;Shan WW;He YX
宫颈癌是世界范围内极其流行的疾病。本研究的目的是阐明亚甲基四氢叶酸还原酶（MTHFR）多态性或甲硫氨酸合酶还原酶（MTRR）多态性与宫颈癌的关系。有 372 名女性进行了基因和叶酸评估。对于MTHFR C677T，三组中C等位基因和T等位基因的分布没有显着差异。然而，MTHFR A1298C 的突变 C 等位基因在癌症组中显着高于正常组。同样，MTRR A66G的突变G等位基因也高于正常组。随着宫颈病变的进展，血清叶酸水平逐渐降低。血清叶酸水平在 4-9ng/ml 和≤4ng/ml 均与宫颈癌风险显着相关。然而，MTHFR C677T 多态性与宫颈癌或 CIN 的风险无关。相反，MTHFR A1298C 多态性可能增加宫颈癌和 CIN 的风险。此外，MTRR A66G多态性仅与宫颈癌风险相关，与CIN无关。
Cervical cancer is an extremely prevalent disease worldwide. The purpose of this study was to illustrate the relationship between methylenetetrahydrofolate reductase (MTHFR) polymorphisms or methionine synthase reductase (MTRR) polymorphisms and cervical cancer. There were 372 women who performed genetic and folic acid assessments. For the MTHFR C677T, there was no significant difference in the distribution of C allele and T allele in the three groups. However, the mutant C allele of MTHFR A1298C was significantly higher in the cancer group than in the normal group. Similarly, the mutant G allele of MTRR A66G was also higher than the normal group. The serum folic acid levels were gradually decreased with the development of cervical lesions. Serum folate levels in 4–9 ng/ml and ≤4 ng/ml were both significantly associated with cervical cancer risk. However, the MTHFR C677T polymorphism was not associated with the risk of cervical cancer or CIN. In contrast, the MTHFR A1298C polymorphism could increase the risk of both cervical cancer and CIN. In addition, the MTRR A66G polymorphism was only associated with the risk of cervical cancer but not CIN.
登录
查看更多内容
DOI：
10.3945/an.116.013516
发表时间：
2017-01
期刊：
Advances in nutrition (Bethesda, Md.)
影响因子：
--
作者：
Schwingshackl L;Boeing H;Stelmach-Mardas M;Gottschald M;Dietrich S;Hoffmann G;Chaimani A
通讯作者：
Chaimani A
影响因子：
3.8
作者：
Jagerstad, Margaretha
通讯作者：
Jagerstad, Margaretha
影响因子：
9.7
作者：
Lambropoulos, AF;Agorastos, T;Kotsis, A
通讯作者：
Kotsis, A
影响因子：
3.7
作者：
Ren Z;Ren P;Yang B;Fang K;Ren S;Liao J;Liu S;Liu L;Peng Z;Dong Q
通讯作者：
Dong Q
DOI：
10.1097/igc.0b013e318272e7e7
发表时间：
2012-11-01
影响因子：
4.8
作者：
Gong, Jiao-Mei;Shen, Yong;Li, Xiao-Fu
通讯作者：
Li, Xiao-Fu