The role of epidermal cytokines in inflammatory skin diseases.

The role of epidermal cytokines in inflammatory skin diseases.
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表皮细胞因子在炎症性皮肤病中的作用。

DOI:
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发表时间:
1990
影响因子:
6.5
通讯作者:
Daniel N. Sauder
Daniel N. Sauder
中科院分区:
医学1区
文献类型:
--
作者:
Daniel N. Sauder

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细胞因子(激素样多肽介质)在炎症和免疫调节反应中起主要作用。皮肤,尤其是皮肤中的角质形成细胞,是许多细胞因子的重要来源,包括白细胞介素1、6、8和造血集落刺激因子。细胞因子通过与携带细胞因子受体的靶细胞相互作用,然后启动一系列细胞相互作用,从而开始其生物作用。某些炎症性皮肤病与细胞因子的过量产生、细胞因子受体的改变或细胞因子的失调有关。虽然数据还很初步,但细胞因子很可能与许多炎症性皮肤病的发病机制有关。
Cytokines (hormone-like polypeptide mediators) play a major role in inflammatory and immunoregulatory responses. Skin, and particularly keratinocytes in the skin, represent a potent source for many cytokines, including interleukins 1, 6, 8, and the hemopoietic colony stimulating factors. Cytokines initiate their biologic action by interacting with target cells bearing cytokine receptors and then initiating a cascade of cellular interactions. Certain inflammatory skin diseases have been associated with overproduction of cytokines, alteration in cytokine receptors, or dysregulation of cytokines. While data is still quite preliminary, it is likely that cytokines contribute to the pathogenesis of many inflammatory skin diseases.
DOI: 10.4049/jimmunol.137.1.245
发表时间: 1986-07
影响因子: 4.4
作者:
Michael Loran Dustin;R. Rothlein;A. Bhan;C. Dinarello;T. Springer
通讯作者: Michael Loran Dustin;R. Rothlein;A. Bhan;C. Dinarello;T. Springer
DOI: 10.1073/pnas.86.16.6367
发表时间: 1989-08-01
影响因子: 11.1
作者:
GROSSMAN, RM;KRUEGER, J;GOTTLIEB, AB
通讯作者: GOTTLIEB, AB
人表皮细胞中与白细胞介素1同源的mRNA表达。
DOI: 10.1111/1523-1747.ep12469041
发表时间: 1987
期刊: The Journal of investigative dermatology
影响因子: --
作者:
Bell,TV;Harley,CB;Stetsko,D;Sauder,DN
通讯作者: Sauder,DN