Uric Acid and Cognitive Function in Older Individuals.
Uric Acid and Cognitive Function in Older Individuals.
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DOI：
10.3390/nu10080975
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发表时间：
2018-07-27
期刊：
影响因子：
5.9
通讯作者：
Meschi T
中科院分区：
文献类型：
--
作者：
Tana C;Ticinesi A;Prati B;Nouvenne A;Meschi T
高尿酸血症在流行病学研究中已被认为是独立的心血管危险因素。然而，由于其抗氧化特性，尿酸也可以发挥有益的功能，这在神经退行性疾病的背景下可能特别重要。在本文中，我们批判性地修改了老年人血清尿酸水平与认知功能之间关系的证据，重点关注认知障碍（阿尔茨海默病、帕金森痴呆和血管性痴呆）的病因学以及尿酸、痴呆和饮食之间的相互作用。尽管现有研究存在高度异质性，但由于研究人群的特征和认知功能障碍评估方法的不同，我们得出结论，根据痴呆的病因，血清尿酸可能以不同的方式调节认知功能。目前的研究确实表明，尿酸可能对阿尔茨海默病和帕金森痴呆症发挥神经保护作用，低尿酸血症是疾病进展更快的危险因素，也是营养不良的可能标志。相反，高血清尿酸可能会对血管性痴呆的病程产生负面影响。需要进一步的研究来阐明尿酸在不同痴呆类型中的生理病理作用及其临床预后意义。
Hyperuricemia has been recognized as an independent cardiovascular risk factor in epidemiological studies. However, uric acid can also exert beneficial functions due to its antioxidant properties, which may be particularly relevant in the context of neurodegenerative diseases. In this paper, we critically revise the evidence on the relationship between serum uric acid levels and cognitive function in older individuals, focusing on the etiology of cognitive impairment (Alzheimer’s disease, Parkinson’s dementia, and vascular dementia) and on the interactive connections between uric acid, dementia, and diet. Despite high heterogeneity in the existing studies, due to different characteristics of studied populations and methods of cognitive dysfunction assessment, we conclude that serum uric acid may modulate cognitive function in a different way according to the etiology of dementia. Current studies indeed demonstrate that uric acid may exert neuroprotective actions in Alzheimer’s disease and Parkinson’s dementia, with hypouricemia representing a risk factor for a quicker disease progression and a possible marker of malnutrition. Conversely, high serum uric acid may negatively influence the disease course in vascular dementia. Further studies are needed to clarify the physio-pathological role of uric acid in different dementia types, and its clinical-prognostic significance.
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影响因子：
19.6
作者：
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通讯作者：
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DOI：
10.1159/000170883
发表时间：
2009
期刊：
Neuro-degenerative diseases
影响因子：
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4.1
作者：
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DOI：
10.3233/jad-2010-1330
发表时间：
2010
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Bowman GL;Shannon J;Frei B;Kaye JA;Quinn JF
通讯作者：
Quinn JF