Relation of kidney function and albuminuria with atrial fibrillation (from the Heart and Soul Study).
Relation of kidney function and albuminuria with atrial fibrillation (from the Heart and Soul Study).
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肾功能和蛋白尿与心房颤动的关系（来自心与灵魂研究）。
DOI：
10.1016/j.amjcard.2009.07.026
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发表时间：
2009-12-01
影响因子：
2.8
通讯作者：
Ix, Joachim H.
中科院分区：
文献类型：
--
作者：
McManus, David D.;Corteville, David C. M.;Shlipak, Michael G.;Whooley, Mary A.;Ix, Joachim H.
房颤（AF）在终末期肾病（ESRD）中很常见，但肾功能中度下降或蛋白尿与AF之间的关系尚不确定。在956例门诊冠心病（CHD）患者中，我们通过3种方法（基于半胱氨酸蛋白酶抑制剂C [eGFRcys]和基于肌酐[eGFRCr]估计的肾小球滤过率和尿白蛋白/肌酐比值[ACR]）评估肾功能，并通过体表心电图评估普遍AF。多变量逻辑回归评估了每个肾功能指标与AF的相关性。平均eGFRcys为71 ± 23 ml/min/1.73 m2，中位ACR为10 mg/g（四分位数范围6 - 19 mg/g）。40例受试者（4%）普遍存在AF。在对传统CVD风险因素进行多变量校正后，与eGFRcys处于最高三分位数（eGFRcys > 79）的受试者相比，eGFRcys处于最低三分位数（eGFRcys < 62）的受试者发生AF的几率高出3倍以上（OR 3.43; 95%CI 1.18 - 9.97）。进一步调整ACR后，这种相关性仍然显著（OR 3.37; 95% 1.02 - 11.14）。eGFRCr的结果相似，但未达到统计学显著性（OR 1.59; 95% CI 0.57 - 4.40）。ACR最高三分位数（ACR > 15 mg/g）的参与者发生AF的几率是ACR最低三分位数（ACR < 7 mg/g）的参与者的4倍以上;在调整eGFRcys（OR 4.36; 95% CI 1.45 - 13.05）或eGFRCr（OR 4.61; 95% CI 1.56 - 13.66）后，这种相关性仍然显著。总之，在门诊CHD患者中，较低的eGFRcys和较高的ACR均与普遍的AF相关，彼此独立。
Atrial fibrillation (AF) is common in end-stage renal disease (ESRD), but the relationship between more modest decrements in kidney function or albuminuria with AF is uncertain. Among 956 outpatients with coronary heart disease (CHD), we assessed kidney function by 3 methods (cystatin C-based [eGFRcys] and creatinine-based [eGFRCr] estimated glomerular filtration rate, and urinary albumin-to-creatinine ratio [ACR]) and prevalent AF by surface electrocardiogram. Multivariable logistic regression evaluated the associations of each measure of kidney function with AF. The mean eGFRcys was 71 ± 23 ml/min/1.73m2 and median ACR was 10 mg/g (interquartile range 6 – 19 mg/g). Forty subjects (4%) had prevalent AF. Compared to participants with eGFRcys in the highest tertile (eGFRcys > 79), those with eGFRcys in the lowest tertile (eGFRcys < 62) had more than 3-fold greater odds of AF (OR 3.43; 95% CI 1.18 – 9.97) after multivariate adjustment for traditional CVD risk factors. This association remained significant with further adjustment for ACR (OR 3.37; 95% 1.02 – 11.14). Results were similar for eGFRCr, but did not reach statistical significance (OR 1.59; 95% CI 0.57 – 4.40). Participants with ACR in the highest tertile (ACR > 15 mg/g) had more than 4-fold greater odds of AF compared to participants in the lowest ACR tertile (ACR < 7 mg/g); an association that remained significant after adjustment for eGFRcys (OR 4.36; 95% CI 1.45 – 13.05) or eGFRCr (OR 4.61; 95% CI 1.56 – 13.66). In conclusion, among outpatients with CHD, lower eGFRcys and higher ACR are each associated with prevalent AF, independent of one another.
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影响因子：
2.8
作者：
Iguchi, Yasuyuki;Kimura, Kazumi;Shibazaki, Kensaku
通讯作者：
Shibazaki, Kensaku
影响因子：
3
作者：
Bozbas, Huseyin;Atar, Ilyas;Ozin, Bulent
通讯作者：
Ozin, Bulent
影响因子：
4.8
作者：
Vázquez, E;Sánchez-Perales, C;Perez, V
通讯作者：
Perez, V
影响因子：
13.2
作者：
Stevens, Lesley A.;Coresh, Josef;Levey, Andrew S.
通讯作者：
Levey, Andrew S.
DOI：
10.1111/j.1524-6175.2004.4064.x
发表时间：
2004-11-01
期刊：
Journal of clinical hypertension (Greenwich, Conn.)
影响因子：
--
作者：
Toto, Robert D
通讯作者：
Toto, Robert D