The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
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DOI：
10.1007/s00424-009-0682-y
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发表时间：
2009-09
影响因子：
4.5
通讯作者：
Zhu, Michael X.
中科院分区：
文献类型：
--
作者：
Galione, Antony;Evans, A. Mark;Ma, Jianjie;Parrington, John;Arredouani, Abdelilah;Cheng, Xiaotong;Zhu, Michael X.
关键词：
In this review we describe the background and implications of our recent discovery that Two pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localization to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca2+ mobilization. In addition, we describe how TPCs may also trigger further Ca2+ release by coupling to the endoplasmic reticular stores through activation of IP3 receptors and ryanodine receptors.
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影响因子：
6.1
作者：
Kamphoven, JHJ;de Ruiter, MM;Reuser, AJJ
通讯作者：
Reuser, AJJ
影响因子：
20.1
作者：
Boittin, FX;Galione, A;Evans, AM
通讯作者：
Evans, AM
影响因子：
3.9
作者：
Galione, A.
通讯作者：
Galione, A.
影响因子：
5.6
作者：
Gambara, Guido;Billington, Richard A.;Filippini, Antonio
通讯作者：
Filippini, Antonio
DOI：
10.1083/jcb.150.3.581
发表时间：
2000-08-07
期刊：
The Journal of cell biology
影响因子：
--
作者：
Berg I;Potter BV;Mayr GW;Guse AH
通讯作者：
Guse AH