How Gut Microbiota Are Shaped by Pattern Recognition Receptors in Colitis and Colorectal Cancer.
How Gut Microbiota Are Shaped by Pattern Recognition Receptors in Colitis and Colorectal Cancer.
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结肠炎和结直肠癌中的模式识别受体如何塑造肠道微生物群。
DOI：
10.3390/cancers14153821
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发表时间：
2022-08-06
期刊：
影响因子：
5.2
通讯作者：
Liu, Zhiping
中科院分区：
文献类型：
--
作者：
Qing, Furong;Xie, Tao;Xie, Lu;Guo, Tianfu;Liu, Zhiping
结肠炎、结直肠癌等肠道炎症性疾病的发病机制复杂，肠道菌群失调被认为是一个重要的致病因素。炎症通常是由模式识别受体的激活引起的。然而，这些先天免疫受体与肠道微生物群之间的关系尚不完全清楚。本研究表明，模式识别受体不仅可以识别病原体并启动炎症信号转导诱导免疫反应，还可以影响肠道微生物的组成，从而通过多种机制影响肠道炎症和癌症的发展。这提示先天免疫受体及其相关分子的修饰可能是通过调节肠道微生物群来治疗结肠炎和结直肠癌的治疗靶点。肠道菌群紊乱与包括结肠炎和结直肠癌（CRC）在内的各种肠道疾病的发生密切相关。具体来说，有益细菌和肠道代谢物的产生可能会减缓某些肠道疾病的发展。近年来，模式识别受体（PRRs）不仅识别病原体并启动炎症信号转导诱导免疫反应，而且还影响肠道微生物的组成。然而，在结肠炎和结直肠癌的情况下，PRRs调节肠道微生物群的机制很少被系统地回顾。因此，在本文中，我们总结了我们对PRRs如何塑造肠道微生物群及其如何影响结肠炎和结直肠癌发展的理解的最新进展。
The pathogenesis of intestinal inflammatory disorders such as colitis and colorectal cancer is complicated and dysregulation of gut microbiota is considered an important contributing factor. Inflammation is often initiated by the activation of pattern recognition receptors. However, the relationship between these innate immune receptors and gut microbiota is not fully understood. Here, we show that pattern recognition receptors not only recognize pathogens and initiate inflammatory signal transduction to induce immune responses, but also influence the composition of intestinal microorganisms, thus affecting the development of intestinal inflammation and cancer through various mechanisms. This suggests that the modification of innate immune receptors and relevant molecules could be therapeutic targets for the treatment of colitis and colorectal cancer by regulating gut microbiota. Disorders of gut microbiota have been closely linked to the occurrence of various intestinal diseases including colitis and colorectal cancer (CRC). Specifically, the production of beneficial bacteria and intestinal metabolites may slow the development of some intestinal diseases. Recently, it has been proposed that pattern recognition receptors (PRRs) not only recognize pathogens and initiate inflammatory signal transduction to induce immune responses but also influence the composition of intestinal microorganisms. However, the mechanisms through which PRRs regulate gut microbiota in the setting of colitis and CRC have rarely been systematically reviewed. Therefore, in this paper, we summarize recent advances in our understanding of how PRRs shape gut microbiota and how this influences the development of colitis and CRC.
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肠道微生物群、NLR 蛋白和肠道稳态。
DOI：
10.1084/jem.20181832
发表时间：
2020-10-05
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Guo H;Gibson SA;Ting JPY
通讯作者：
Ting JPY
影响因子：
4.6
作者：
Butera A;Di Paola M;Pavarini L;Strati F;Pindo M;Sanchez M;Cavalieri D;Boirivant M;De Filippo C
通讯作者：
De Filippo C
影响因子：
8
作者：
Amendola A;Butera A;Sanchez M;Strober W;Boirivant M
通讯作者：
Boirivant M
影响因子：
8.8
作者：
Ahn J;Son S;Oliveira SC;Barber GN
通讯作者：
Barber GN
影响因子：
5.6
作者：
Gryp, Tessa;Huys, Geert R. B.;Vaneechoutte, Mario
通讯作者：
Vaneechoutte, Mario