Development of Lymphatic Capillary Network Along the Alveolar Walls of Autopsied Human Lungs with Pneumonia.
Development of Lymphatic Capillary Network Along the Alveolar Walls of Autopsied Human Lungs with Pneumonia.
复制标题
肺炎尸检人肺沿肺泡壁毛细淋巴管网络的发育。
DOI：
10.1089/lrb.2015.0042
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Yamauchi K.
中科院分区：
文献类型：
--
作者：
120.Yamashita M;Niisato M;Hanasaka T;Iwama N;Takahashi T;Sugai T;Ono M;Yamauchi K.
目的：研究肺炎尸检标本中淋巴管的形态特征。方法：对20例并发肺炎尸检标本和10例非肺炎对照身体肺组织石蜡包埋标本进行免疫组织化学染色，检测肺组织中抗泊多拉宁、血管内皮生长因子受体-3(VEGFR-3)、CD34、血管内皮生长因子(VEGF)-C、VEGF-D、CD73和CD163的血管密度。然而，在一半肺炎身体中，沿着肺泡间隔出现了并排的珠状排列的足平台+细胞网络；然而，在对照身体中没有这一网络。与正常淋巴管相比，该网络中的PodoPlanin+细胞的特征是表达较弱，偶见导管结构。虽然Podoplan in+细胞不与VEGFR-3共表达，但部分网络与CD73+传入淋巴管相连。该网络与CD34+毛细血管相互交织，提示该网络代表毛细淋巴管。CD163+巨噬细胞的数量在有网络的个体中比没有网络的个体显著增加，而中性粒细胞显著减少。CD163+巨噬细胞和有网状结构的身体中的II型上皮细胞均可见VEGF-C的表达。结论：尸检肺炎患者的肺泡间隔内有淋巴管网络的形成，而不是通常的淋巴管生成。
Background:Limited information is available regarding the lymphatic vasculature during pneumonia.Objective:To characterize lymphatic vasculatures in autopsied cadavers with pneumonia.Methods:Paraffin-embedded lung tissues obtained from 20 autopsied cadavers with complicated pneumonia and 10 control cadavers without pneumonia were used for immunohistochemical analyses using primary antibodies against podoplanin, vascular endothelial growth factor receptor-3 (VEGFR-3), CD34, vascular endothelial growth factor (VEGF)-C, VEGF-D, CD73, and CD163.Results:There was no difference in the vascular density of podoplanin+usual lymphatics between the individuals with and without pneumonia. In half of the cadavers with pneumonia, however, a network of podoplanin+cells lying together in a side-by-side bead-like arrangement appeared along the alveolar septa; however, this was absent in the control cadavers. The podoplanin+cells in the network were characterized by a weaker expression of podoplanin, relative to usual lymphatics, and the occasional presence of ductal structures. Although podoplanin+cells were not coexpressed with VEGFR-3, a part of the network was connected to CD73+afferent lymphatics. The network showed an intertwined relationship with CD34+capillaries, suggesting that the network represents lymphatic capillaries. The number of CD163+macrophages was significantly increased in individuals with the network than those without the network, while a significant decrease in neutrophils was observed. VEGF-C expressed in CD163+macrophages and type II epithelial cells was observed in the cadavers with the network.Conclusion:The development of lymphatic capillary networks along the alveolar septa rather than the usual lymphangiogenesis was noted in autopsied individuals with pneumonia.
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影响因子：
--
作者：
Zhou, Quan;Guo, Ruolin;Wood, Ronald;Boyce, Brendan F.;Liang, Qianqian;Wang, Yong-Jun;Schwarz, Edward M.;Xing, Lianping
通讯作者：
Xing, Lianping
基于细胞外基质形态定量的特发性肺纤维化成纤维细胞灶中纤维形成过程的定义。
影响因子：
3.3
作者：
M. Yamashita;K. Yamauchi;R. Chiba;N. Iwama;F. Date;N. Shibata;H. Kumagai;J. Risteli;Shinobu Sato;Tohru Takahashi;M. Ono
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M. Ono
组织蛋白酶 L 可以保护小鼠免受支原体感染，并且对于气道淋巴管生成至关重要。
DOI：
10.1165/rcmb.2013-0016oc
发表时间：
2013
影响因子：
6.4
作者：
Xu,Xiang;Greenland,John;Baluk,Peter;Adams,Alicia;Bose,Oishee;McDonald,DonaldM;Caughey,GeorgeH
通讯作者：
Caughey,GeorgeH
正常人肺小叶内、小叶间和胸膜淋巴管的形态分析
影响因子：
2.4
作者：
F. Sozio;A. Rossi;E. Weber;D. Abraham;A. Nicholson;A. Wells;E. Renzoni;P. Sestini
通讯作者：
P. Sestini
影响因子：
3.2
作者：
Kambouchner, Marianne;Bernaudin, Jean-Francois
通讯作者：
Bernaudin, Jean-Francois