Trends in the prevalence of atrophic gastritis and Helicobacter pylori infection over a 10‑year period in Japan: The ROAD study 2005‑2015.
Trends in the prevalence of atrophic gastritis and Helicobacter pylori infection over a 10‑year period in Japan: The ROAD study 2005‑2015.
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DOI：
10.3892/mco.2023.2649
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发表时间：
2023-07
影响因子：
1.2
通讯作者：
Ichinose M
中科院分区：
文献类型：
--
作者：
Inoue I;Yoshimura N;Iidaka T;Horii C;Muraki S;Oka H;Kawaguchi H;Akune T;Maekita T;Mure K;Nakamura K;Tanaka S;Ichinose M
很少有大型人群研究调查了日本萎缩性胃炎 (AG) 和幽门螺杆菌感染的患病率。本研究的目的是估计按年龄划分的 AG 和幽门螺杆菌感染的患病率，并使用基于大型人群的队列数据调查 2005 年至 2016 年日本的变化率。该队列共有 3,596 名参与者（基线调查（2005-2006 年）为 1,690 名，第四次调查（2015-2016 年为 1,906 名））年龄在 18 岁至 97 岁之间。在基线和第四次调查中，根据幽门螺杆菌抗体滴度和胃蛋白酶原水平的血清学检测，检查了 AG 和幽门螺杆菌感染的患病率。基线时，AG 和幽门螺杆菌感染的患病率分别为 40.1%（男性 44.1%；女性 38.0%）和 52.2%（男性 54.8%；女性 50.8%）。 AG 血清阳性率在 10 年内从 40.1% 显着下降至 25.8%。 10 年间，幽门螺杆菌血清阳性率从 52.2% 显着下降至 35.5%。按年龄分层，AG患病率随年龄增长呈上升趋势，而H. pylori感染率随年龄增长而上升，除老年组外，呈倒U型相关。在这项以 10 年为间隔的基于人群的横断面研究中，AG 和幽门螺杆菌感染的患病率显着下降。这种变化可能会影响幽门螺杆菌相关疾病的患病率，包括与幽门螺杆菌引起的全身亚临床炎症和胃酸过少相关的胃外疾病，例如结直肠肿瘤和动脉硬化。
Few large population-based studies have examined the prevalence of atrophic gastritis (AG) and Helicobacter pylori infection in Japan. The purpose of the present study was to estimate the prevalence of AG and H. pylori infection by age, in addition to investigating their change rates from 2005 to 2016 in Japan using data from a large population-based cohort. A total of 3,596 participants [1,690 in the baseline survey (2005-2006) and 1,906 at the fourth survey (2015-2016)] aged 18 to 97 years were included in the cohort. The prevalence of AG and H. pylori infection were examined at baseline and in the fourth survey based on serological tests for the H. pylori antibody titer and pepsinogen levels. The prevalence of AG and H. pylori infection were 40.1% (men, 44.1%; women, 38.0%) and 52.2% (men, 54.8%; women, 50.8%), respectively, at baseline. AG seropositivity rates showed a significant decrease from 40.1 to 25.8% in 10 years. H. pylori seropositivity rates decreased significantly from 52.2 to 35.5% in 10 years. Stratified for age, the prevalence of AG showed an increasing trend with age, whereas the prevalence of H. pylori infection increased with aging, except for in the elderly group, showing an inverted U-shaped association. In this population-based, cross-sectional study with a 10-year interval survey, the prevalence of AG and H. pylori infection decreased significantly. This change may influence the prevalence of H. pylori-related diseases, including extra-gastric disorders associated with H. pylori-induced systemic subclinical inflammation and hypochlorhydria, such as colorectal neoplasia and arteriosclerosis.
影响因子：
4.6
作者：
Yu TY;Wei JN;Kuo CH;Liou JM;Lin MS;Shih SR;Hua CH;Hsein YC;Hsu YW;Chuang LM;Lee MK;Hsiao CH;Wu MS;Li HY
通讯作者：
Li HY