The Impact of Gastric Atrophy on the Incidence of Diabetes.
The Impact of Gastric Atrophy on the Incidence of Diabetes.
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DOI：
10.1038/srep39777
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发表时间：
2017-01-03
影响因子：
4.6
通讯作者：
Li HY
中科院分区：
文献类型：
--
作者：
Yu TY;Wei JN;Kuo CH;Liou JM;Lin MS;Shih SR;Hua CH;Hsein YC;Hsu YW;Chuang LM;Lee MK;Hsiao CH;Wu MS;Li HY
胃萎缩导致较低的血浆胃饥饿素、较高的胃泌素分泌、肠道微生物群的变化和改变的饮食营养吸收，这可能与糖尿病的发病率相关。幽门螺杆菌（H.幽门螺杆菌）感染是胃萎缩的主要原因，并且在一些报道中与糖尿病有关。由于没有研究探讨胃萎缩对糖尿病的影响，我们进行了一项前瞻性队列研究，以检查H。幽门感染、胃萎缩和偶发糖尿病。在这项研究中，与没有胃萎缩的受试者相比，胃萎缩的受试者发生糖尿病的风险较低。胃萎缩的程度，用血清胃蛋白酶原（PG）I/II比值来衡量，与年龄、H。pylori IgG滴度、HOMA 2-IR和HOMA2%B。当胃萎缩更广泛时，表现为较低的血清PG I/II比值，糖尿病发病风险较低。另一方面，H.幽门螺杆菌感染和糖尿病的发病率。结论：胃萎缩的存在和程度与H.幽门螺杆菌感染与糖尿病发病有关。需要进一步的研究来调查详细的机制和研究结果的潜在应用，以指导糖尿病筛查和治疗策略。
Gastric atrophy results in lower plasma ghrelin, higher gastrin secretion, a change in gut microbiota, and altered dietary nutrient absorption, which may be associated with the incidence of diabetes. Helicobacter pylori (H. pylori) infection is a major cause of gastric atrophy and is associated with diabetes in some reports. Since there is no study which investigates the impact of gastric atrophy on diabetes, we conduct a prospective cohort study to examine the relationship between H. pylori infection, gastric atrophy, and incident diabetes. In this study, subjects with gastric atrophy had a lower risk of incident diabetes, compared to those without gastric atrophy. The extent of gastric atrophy, measured by serum pepsinogen (PG) I/II ratio, was correlated with age, H. pylori IgG titer, HOMA2-IR, and HOMA2%B. When gastric atrophy is more extensive, presented as a lower serum PG I/II ratio, the risk of incident diabetes is lower. On the other hand, there was no significant association between H. pylori infection and the incidence of diabetes. In conclusion, the presence and the extent of gastric atrophy, but not H. pylori infection, are associated with incident diabetes. Further studies are needed to investigate the detailed mechanisms and the potential applications of the findings to guide diabetes screening and treatment strategies.
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影响因子：
16.2
作者：
Jeon CY;Haan MN;Cheng C;Clayton ER;Mayeda ER;Miller JW;Aiello AE
通讯作者：
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