Multiplatform plasma metabolic and lipid fingerprinting of breast cancer: A pilot control-case study in Colombian Hispanic women.
Multiplatform plasma metabolic and lipid fingerprinting of breast cancer: A pilot control-case study in Colombian Hispanic women.
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DOI：
10.1371/journal.pone.0190958
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Meesters RJW
中科院分区：
文献类型：
--
作者：
Cala MP;Aldana J;Medina J;Sánchez J;Guio J;Wist J;Meesters RJW
乳腺癌（BC）是一种与代谢重编程相关的高度异质性疾病。BC引起的代谢组的变化仍然缺乏来自西班牙裔拉丁人群的数据。在这项试点研究中，代谢组学和脂质组学的方法进行，以建立哥伦比亚西班牙裔妇女与BC的血浆代谢指纹。将来自1H-NMR、GC-MS和LC-MS的数据合并并比较。统计数据显示，在所有分析平台上，乳腺癌和健康受试者之间存在差异。分化代谢产物主要涉及甘油脂、甘油磷脂、氨基酸和脂肪酸代谢。这项研究证明了多平台方法在代谢/脂质指纹图谱研究中的有用性，以拓宽代谢可能变化的前景。我们的研究结果提出了相关的血浆代谢物，这可能有助于更好地了解哥伦比亚西班牙裔女性中BC驱动的潜在代谢变化。特别是对长链脂肪酰基肉毒碱的上调和环磷脂酸（cPA）的下调的理解。此外，乳腺癌的代谢特征与非西班牙裔女性的代谢特征相似，但不完全相同，尽管存在种族差异。
Breast cancer (BC) is a highly heterogeneous disease associated with metabolic reprogramming. The shifts in the metabolome caused by BC still lack data from Latin populations of Hispanic origin. In this pilot study, metabolomic and lipidomic approaches were performed to establish a plasma metabolic fingerprint of Colombian Hispanic women with BC. Data from 1H-NMR, GC-MS and LC-MS were combined and compared. Statistics showed discrimination between breast cancer and healthy subjects on all analytical platforms. The differentiating metabolites were involved in glycerolipid, glycerophospholipid, amino acid and fatty acid metabolism. This study demonstrates the usefulness of multiplatform approaches in metabolic/lipid fingerprinting studies to broaden the outlook of possible shifts in metabolism. Our findings propose relevant plasma metabolites that could contribute to a better understanding of underlying metabolic shifts driven by BC in women of Colombian Hispanic origin. Particularly, the understanding of the up-regulation of long chain fatty acyl carnitines and the down-regulation of cyclic phosphatidic acid (cPA). In addition, the mapped metabolic signatures in breast cancer were similar but not identical to those reported for non-Hispanic women, despite racial differences.
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影响因子：
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作者：
Erickson JW;Cerione RA
通讯作者：
Cerione RA
影响因子：
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作者：
Fan Y;Zhou X;Xia TS;Chen Z;Li J;Liu Q;Alolga RN;Chen Y;Lai MD;Li P;Zhu W;Qi LW
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Qi LW
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56.9
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4.4
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通讯作者：
Fiehn O
影响因子：
2.4
作者：
Abu-Bedair, FA;El-Gamal, BA;El-Aaser, AA
通讯作者：
El-Aaser, AA