Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization.
Multivalent nanoparticle-based vaccines protect hamsters against SARS-CoV-2 after a single immunization.
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DOI：
10.1038/s42003-021-02128-8
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发表时间：
2021-05-19
影响因子：
5.9
通讯作者：
Kane RS
中科院分区：
文献类型：
--
作者：
Chiba S;Frey SJ;Halfmann PJ;Kuroda M;Maemura T;Yang JE;Wright ER;Kawaoka Y;Kane RS
COVID-19大流行继续肆虐，全球SARS-CoV-2感染率、住院率和死亡率有增无减。有效的疫苗仍然是对抗SARS-CoV-2最有希望的方法。然而，尽管COVID-19疫苗试验取得了可喜的成果，但对多剂量的需求以及与疫苗广泛分发和接种相关的挑战仍然令人担忧。在这里，我们设计了MS 2噬菌体的外壳蛋白，并产生了显示多个SARS-CoV-2刺突（S）蛋白拷贝的纳米颗粒。使用这些纳米颗粒作为疫苗产生高中和抗体滴度，并保护叙利亚仓鼠在单次免疫后免受SARS-CoV-2的挑战，肺部未检测到感染性病毒。因此，这种基于纳米颗粒的疫苗平台在单次免疫后提供保护，并可广泛适用于预防SARS-CoV-2和未来具有大流行潜力的病原体。千叶等人描述了使用MS 2噬菌体外壳蛋白来开发用于疫苗应用的多价展示SARS-CoV-2刺突蛋白的纳米载体。该疫苗引发了高中和抗体滴度，并在单次免疫后保护叙利亚仓鼠免受病毒感染。
The COVID-19 pandemic continues to wreak havoc as worldwide SARS-CoV-2 infection, hospitalization, and death rates climb unabated. Effective vaccines remain the most promising approach to counter SARS-CoV-2. Yet, while promising results are emerging from COVID-19 vaccine trials, the need for multiple doses and the challenges associated with the widespread distribution and administration of vaccines remain concerns. Here, we engineered the coat protein of the MS2 bacteriophage and generated nanoparticles displaying multiple copies of the SARS-CoV-2 spike (S) protein. The use of these nanoparticles as vaccines generated high neutralizing antibody titers and protected Syrian hamsters from a challenge with SARS-CoV-2 after a single immunization with no infectious virus detected in the lungs. This nanoparticle-based vaccine platform thus provides protection after a single immunization and may be broadly applicable for protecting against SARS-CoV-2 and future pathogens with pandemic potential. Chiba et al. describe the use of MS2 bacteriophage coat proteins to develop nanocarriers that display the SARS-CoV-2 spike proteins multivalently for vaccine applications. The vaccine elicited high neutralizing antibody titers and protected Syrian hamsters from virus infection after a single immunization.
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影响因子：
9.4
作者：
Addetia A;Crawford KHD;Dingens A;Zhu H;Roychoudhury P;Huang ML;Jerome KR;Bloom JD;Greninger AL
通讯作者：
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影响因子：
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ter Meulen, Jan;van den Brink, Edward N.;Poon, Leo L. M.;Marissen, Wilfred E.;Leung, Cynthia S. W.;Cox, Freek;Cheung, Chung Y.;Bakker, Arjen Q.;Bogaards, Johannes A.;van Deventer, Els;Preiser, Wolfgang;Doerr, Hans Wilhelm;Chow, Vincent T.;de Kruif, John;Peiris, Joseph S. M.;Goudsmit, Jaap
通讯作者：
Goudsmit, Jaap
影响因子：
3
作者：
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通讯作者：
Mastronarde, DN