Interactions and Feedbacks in E-Cadherin Transcriptional Regulation.
Interactions and Feedbacks in E-Cadherin Transcriptional Regulation.
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DOI：
10.3389/fcell.2021.701175
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发表时间：
2021
影响因子：
5.5
通讯作者：
Bulgakova NA
中科院分区：
文献类型：
--
作者：
Ramirez Moreno M;Stempor PA;Bulgakova NA
上皮组织依靠参与细胞之间的粘附来保持其完整性。跨膜蛋白E-钙粘蛋白是介导相邻细胞之间的嗜同性粘附的主要蛋白质，因此是上皮完整性的关键组分之一。钙粘蛋白下调被广泛描述为上皮细胞向间质细胞转化的先决条件，并且是许多类型癌症的标志。由于这种临床重要性，研究主要集中在理解导致这种粘附分子转录抑制的机制上。然而，近年来已经变得明显的是，E-钙粘蛋白的再表达是许多癌症在转移期间进展的主要步骤。在这里，我们回顾了目前已知的E-cadherin转录激活和抑制的分子机制，并强调了各个机制之间复杂的相互作用。然后，我们提出了一个额外的机制，即粘附复合物和异染色质蛋白-1之间的竞争结合STAT 92 E微调E-钙粘蛋白在果蝇的表达水平，但也调节其他基因促进上皮稳健性。我们的假设基于现有的文献和我们的实验证据，并建议细胞表面和细胞核之间的这种反馈为上皮弹性提供了一个强大的范例。
Epithelial tissues rely on the adhesion between participating cells to retain their integrity. The transmembrane protein E-cadherin is the major protein that mediates homophilic adhesion between neighbouring cells and is, therefore, one of the critical components for epithelial integrity. E-cadherin downregulation has been described extensively as a prerequisite for epithelial-to-mesenchymal transition and is a hallmark in many types of cancer. Due to this clinical importance, research has been mostly focused on understanding the mechanisms leading to transcriptional repression of this adhesion molecule. However, in recent years it has become apparent that re-expression of E-cadherin is a major step in the progression of many cancers during metastasis. Here, we review the currently known molecular mechanisms of E-cadherin transcriptional activation and inhibition and highlight complex interactions between individual mechanisms. We then propose an additional mechanism, whereby the competition between adhesion complexes and heterochromatin protein-1 for binding to STAT92E fine-tunes the levels of E-cadherin expression in Drosophila but also regulates other genes promoting epithelial robustness. We base our hypothesis on both existing literature and our experimental evidence and suggest that such feedback between the cell surface and the nucleus presents a powerful paradigm for epithelial resilience.
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影响因子：
3.7
作者：
Stefanatos RK;Bauer C;Vidal M
通讯作者：
Vidal M
影响因子：
21.1
作者：
Cai J;Culley MK;Zhao Y;Zhao J
通讯作者：
Zhao J
影响因子：
8
作者：
Cowling, V. H.;Cole, M. D.
通讯作者：
Cole, M. D.
DOI：
10.1073/pnas.1308663111
发表时间：
2014-04-08
影响因子：
11.1
作者：
Daugherty, Rebecca L.;Serebryannyy, Leonid;Gottardi, Cara J.
通讯作者：
Gottardi, Cara J.
影响因子：
4
作者：
Bolós, V;Peinado, H;Cano, A
通讯作者：
Cano, A