Low prevalence of mismatch repair deficiency in Chinese colorectal cancers: a multicenter study.
Low prevalence of mismatch repair deficiency in Chinese colorectal cancers: a multicenter study.
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中国结直肠癌错配修复缺陷发生率低：一项多中心研究
DOI：
10.1093/gastro/goaa006
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发表时间：
2020-10
影响因子：
3.6
通讯作者：
Ding PR
中科院分区：
文献类型：
--
作者：
Jiang W;Sui QQ;Li WL;Ke CF;Ling YH;Liao LE;Zhu Z;Cai MY;Luo J;Mao LL;Zhang HZ;Wan DS;Pan ZZ;Ju HX;Ding PR
尽管已建议所有结直肠癌（CRC）患者普遍进行错配修复缺陷（dMMR）检测，但缺乏中国人群的相关证据。在此，我们调查了一个大型中国结直肠癌队列中dMMR患者的患病率和临床病理学特征。我们纳入了2010年8月至2016年9月期间在四家中国医疗中心接受治疗的7，373名CRC患者。记录患者的基线特征和病理特征。比较MLH 1/PMS 2缺陷型（dMLH 1/PMS 2）和MSH 2/MSH 6缺陷型（dMSH 2/MSH 6）患者的临床病理特征。在研究的患者中，654例（8.9%）被确定为dMMR CRC，其中401例（61.3%）为男性，中位年龄为55岁（范围：22-87岁）; 355例（54.3%）患有基于美国癌症联合委员会第8版的II期CRC。dMLH 1/PMS 2组和dMSH 2/MSH 6组的患病率分别为51.5%（337/654）和25.1%（164/654）。与dMSH 2/MSH 6患者相比，dMLH 1/PMS 2患者年龄更大（57岁vs 52岁，P < 0.001），更可能是女性（45.7% vs 31.5%，P = 0.004），肿瘤易位于结肠右侧（59.0%vs47.6%，P = 0.015），有肿瘤家族史的可能性较小（29.7%vs43.3%，P = 0.003）。中国结直肠癌患者中dMMR的患病率较低，尤其是dMLH 1/PMS 2组。不同dMMR亚组的临床病理特征不同。
Although universal testing for mismatch repair deficiency (dMMR) has been recommended to all colorectal cancer (CRC) patients, related evidence for the Chinese population is lacking. Here, we investigated the prevalence and clinicopathological features of dMMR patients in a large Chinese CRC cohort. We included 7,373 CRC patients treated at four Chinese medical centers between August 2010 and September 2016. Patients’ baseline characteristics and pathological features were recorded. The clinicopathological features were compared between patients with MLH1/PMS2 deficiency (dMLH1/PMS2) and MSH2/MSH6 deficiency (dMSH2/MSH6). Among the investigated patients, 654 (8.9%) were identified with dMMR CRCs and, of them, 401 (61.3%) were males, with a median age of 55 years (range, 22–87 years); 355 (54.3%) had stage II CRC based on American Joint Committee on Cancer 8th edition. The prevalence of the dMLH1/PMS2 group and the dMSH2/MSH6 group were 51.5% (337/654) and 25.1% (164/654), respectively. Compared with dMSH2/MSH6 patients, those with dMLH1/PMS2 were older (57 vs 52 years, P < 0.001), more likely to be female (45.7% vs 31.5%, P = 0.004), prone to having tumors located in the right-hand side of the colon (59.0% vs 47.6%, P = 0.015), and less likely to have a family history of tumors (29.7% vs 43.3%, P = 0.003). The prevalence of dMMR in Chinese CRC patients was low, especially in the dMLH1/PMS2 group. The clinicopathological features were different between dMMR subgroups.
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影响因子：
29.4
作者：
Haraldsdottir S;Hampel H;Tomsic J;Frankel WL;Pearlman R;de la Chapelle A;Pritchard CC
通讯作者：
Pritchard CC
影响因子：
16.2
作者：
Feng, Rui-Mei;Zong, Yi-Nan;Xu, Rui-Hua
通讯作者：
Xu, Rui-Hua
影响因子：
2.8
作者：
Chou, Chia-Lin;Lin, Jen-Kou;Chang, Shin-Ching
通讯作者：
Chang, Shin-Ching
影响因子：
24.5
作者：
Møller P;Seppälä T;Bernstein I;Holinski-Feder E;Sala P;Evans DG;Lindblom A;Macrae F;Blanco I;Sijmons R;Jeffries J;Vasen H;Burn J;Nakken S;Hovig E;Rødland EA;Tharmaratnam K;de Vos Tot Nederveen Cappel WH;Hill J;Wijnen J;Green K;Lalloo F;Sunde L;Mints M;Bertario L;Pineda M;Navarro M;Morak M;Renkonen-Sinisalo L;Frayling IM;Plazzer JP;Pylvanainen K;Sampson JR;Capella G;Mecklin JP;Möslein G;Mallorca Group (http://mallorca-group.eu)
通讯作者：
Mallorca Group (http://mallorca-group.eu)
影响因子：
6.4
作者：
Jiang, Wu;Cai, Mu-Yon;Ding, Pei-Rong
通讯作者：
Ding, Pei-Rong