The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis
The effect of pregnancy vitamin D supplementation on offspring bone mineral density in childhood: a systematic review and meta-analysis
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妊娠期补充维生素 D 对后代儿童期骨矿物质密度的影响：系统评价和荟萃分析
DOI：
10.1007/s00198-023-06751-5
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发表时间：
2023
影响因子：
4
通讯作者：
Moon R
中科院分区：
文献类型：
--
作者：
Moon R
对孕期补充中、大剂量维生素D对子代骨矿化影响的系统回顾和荟萃分析发现，补充维生素D对4~6岁子代骨密度(BMD)有积极影响，但对骨矿含量影响较小。目的对孕期补充维生素D对子代骨密度(BMD)的影响进行系统回顾和Meta分析。方法对已发表的产前补充维生素D的RCT进行文献检索，采用MEDLINE和EMBASE对子代BMD或骨矿含量(BMC)进行双能X射线吸收法(DXA)评估。使用Cochrane Risk of Bias 2工具评估偏倚风险。研究结果被分成两个年龄组的子女评估：新生儿期和早期儿童(3-6岁)。用Revman 5.4.1进行随机效应荟萃分析，得到标准化平均差(SMD)(95%可信区间)。结果5项随机对照试验符合子代BMD或BMC评估；3250名妇女在这些研究中被随机分组。2项研究的偏倚风险较低，3项研究的偏倚风险较低，3项研究的补充方案和使用的对照(3项研究使用安慰剂，2项研究使用400国际单位/天的胆钙素)各不相同，但在所有研究中，与对照组相比，干预增加了孕妇的25-羟基维生素D水平。两项评估新生儿期骨密度的试验(TOTALN= 690)发现两组间没有差异，但没有进行荟萃分析，因为一项试验代表了该年龄段研究对象的96.4%。三项试验评估了4-6岁的后代全身无头骨密度。补充维生素D的母亲所生的孩子骨密度较高[0.16SD(95%可信区间0.05，0.27)，n= 1358]，对骨矿含量的影响较小[0.07SD(95%CI − 0.04，0.19)，n= 1351]。然而，对三项试验的荟萃分析表明，怀孕期间补充中到高剂量的维生素D可能会增加儿童早期的后代骨密度，但需要进一步的试验来证实这一发现。(PROSPERO CRD42021288682；没有收到资金)。
Systematic review and meta-analysis of the effect of moderate- to high-dose vitamin D supplementation in pregnancy on offspring bone mineralisation found a positive effect of vitamin D supplementation on offspring bone mineral density (BMD) at age 4–6 years, with a smaller effect on bone mineral content.PurposeA systematic review and meta-analysis was performed to assess the effect of pregnancy vitamin D supplementation on offspring bone mineral density (BMD) in childhood.MethodsA literature search was conducted for published RCTs of antenatal vitamin D supplementation with assessment of offspring BMD or bone mineral content (BMC) by dual-energy X-ray absorptiometry (DXA) using MEDLINE and EMBASE up to 13th July 2022. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Study findings were grouped in two age groups of offspring assessment: neonatal period and early childhood (3–6 years). Random-effects meta-analysis of the effect on BMC/BMD at 3–6 years was performed using RevMan 5.4.1, yielding standardised mean difference (SMD) (95% CI).ResultsFive RCTs were identified with offspring assessment of BMD or BMC; 3250 women were randomised within these studies. Risk of bias was low in 2 studies and “of concern” in 3. Supplementation regimes and the control used (3 studies used placebo and 2 used 400 IU/day cholecalciferol) varied, but in all studies the intervention increased maternal 25-hydroxvitamin D status compared to the control group. Two trials assessing BMD in the neonatal period (totaln= 690) found no difference between groups, but meta-analysis was not performed as one trial represented 96.4% of those studied at this age. Three trials assessed offspring whole-body-less-head BMD at age 4–6 years. BMD was higher in children born to mothers supplemented with vitamin D [0.16 SD (95% confidence interval 0.05, 0.27),n= 1358] with a smaller effect on BMC [0.07 SD (95% CI − 0.04, 0.19),n= 1351].ConclusionsThere are few RCTs published to address this question, and these are inconsistent in methodology and findings. However, meta-analysis of three trials suggests moderate- to high-dose vitamin D supplementation in pregnancy might increase offspring BMD in early childhood, but further trials are required to confirm this finding. (Prospero CRD42021288682; no funding received).
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影响因子：
3.7
作者：
Page MJ;McKenzie JE;Bossuyt PM;Boutron I;Hoffmann TC;Mulrow CD;Shamseer L;Tetzlaff JM;Akl EA;Brennan SE;Chou R;Glanville J;Grimshaw JM;Hróbjartsson A;Lalu MM;Li T;Loder EW;Mayo-Wilson E;McDonald S;McGuinness LA;Stewart LA;Thomas J;Tricco AC;Welch VA;Whiting P;Moher D
通讯作者：
Moher D
影响因子：
4.1
作者：
Moon, Rebecca J.;D'Angelo, Stefania;Harvey, Nicholas C.
通讯作者：
Harvey, Nicholas C.
影响因子：
9.8
作者：
Ruecker, Gerta;Cates, Christopher J.;Schwarzer, Guido
通讯作者：
Schwarzer, Guido
DOI：
10.3945/ajcn.115.114603
发表时间：
2016-02
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
C. Wall;A. Stewart;C. Camargo;R. Scragg;E. Mitchell;A. Ekeroma;J. Crane;Tania Milne;Judy Rowden;R. Horst;C. Grant
通讯作者：
C. Wall;A. Stewart;C. Camargo;R. Scragg;E. Mitchell;A. Ekeroma;J. Crane;Tania Milne;Judy Rowden;R. Horst;C. Grant
影响因子：
4
作者：
Viljakainen, H. T.;Korhonen, T.;Hytinantti, T.;Laitinen, E. K. A.;Andersson, S.;Makitie, O.;Lamberg-Allardt, C.
通讯作者：
Lamberg-Allardt, C.