Maternal vitamin D status affects bone growth in early childhood--a prospective cohort study.
Maternal vitamin D status affects bone growth in early childhood--a prospective cohort study.
复制标题
DOI：
10.1007/s00198-010-1499-4
复制
发表时间：
2011-03
影响因子：
4
通讯作者：
Lamberg-Allardt, C.
中科院分区：
文献类型：
--
作者：
Viljakainen, H. T.;Korhonen, T.;Hytinantti, T.;Laitinen, E. K. A.;Andersson, S.;Makitie, O.;Lamberg-Allardt, C.
在这项前瞻性研究中，对87名儿童从出生到14个月进行了随访，并提供了怀孕期间母亲维生素D状况的数据。出生后补充维生素D可改善维生素D状况，但仅部分消除了胎儿期母体维生素D状况引起的骨变量差异。尽管产后营养状况得到改善，但宫内营养缺乏可能会产生永久性后果。我们评估了产前和产后维生素D状况对婴儿早期骨参数的作用。对87名儿童从出生到14个月进行了随访。背景数据通过问卷调查和3天饮食记录收集。在14个月时，通过外周计算机断层扫描（pQCT）测量左侧胫骨的骨变量。测定血清25-OHD和骨转换标志物。研究结果与孕妇怀孕期间的维生素D状况进行了比较。根据怀孕期间的维生素D状况，将儿童分为两组。尽管基线时S-25-OHD存在差异（中位数36.3 vs. 52.5 nmol/l，p < 0.001），但低D组和高D组14个月时的数值相似（63 vs. 66 nmol/l，p = 0.58）。尽管维生素D总摄入量相似（平均12.3 μg/天），但低D组血清25-OHD增加更多（p < 0.001）。在低D组中，出生时胫骨骨矿物质含量（BMC）较低，但BMC增加较大（多变量方差分析[MANOVA]; p = 0.032），导致两组在14个月时的BMC相似。在高D组中，基线时胫骨总骨横截面积较高;差异在14个月时持续存在（MANOVA; p = 0.068）。两组骨密度（BMD）和ΔBMD相似。出生后补充维生素D可改善维生素D状况，但仅部分消除了胎儿期母体维生素D状况引起的骨变量差异。应进一步注意改善怀孕期间的维生素D状况。
In this prospective study, 87 children were followed up from birth to 14 months with data on maternal vitamin D status during the pregnancy. Postnatal vitamin D supplementation improved vitamin D status but only partly eliminated the differences in bone variables induced by maternal vitamin D status during the fetal period. Intrauterine nutritional deficits may have permanent consequences despite improved nutritional status postnatally. We evaluated the role of prenatal and postnatal vitamin D status on bone parameters in early infancy. Eighty-seven children were followed from birth to 14 months. Background data were collected with a questionnaire and a 3-day food record. At 14 months bone variables were measured with peripheral computed tomography (pQCT) from the left tibia. Serum 25-OHD and bone turnover markers were determined. Findings were compared with maternal vitamin D status during pregnancy. The children were divided into two groups based on vitamin D status during pregnancy. Despite discrepant S-25-OHD at baseline (median 36.3 vs. 52.5 nmol/l, p < 0.001), the values at 14 months were similar (63 vs. 66 nmol/l, p = 0.58) in Low D and High D. Serum 25-OHD increased more in Low D (p < 0.001) despite similar total intake of vitamin D (mean 12.3 μg/day). In Low D, tibial bone mineral content (BMC) was lower at birth but BMC gain was greater (multivariate analysis of variance [MANOVA]; p = 0.032) resulting in similar BMC at 14 months in the two groups. In High D, tibial total bone cross-sectional area was higher at baseline; the difference persisted at 14 months (MANOVA; p = 0.068). Bone mineral density (BMD) and ΔBMD were similar in the two groups. Postnatal vitamin D supplementation improved vitamin D status but only partly eliminated the differences in bone variables induced by maternal vitamin D status during the fetal period. Further attention should be paid to improving vitamin D status during pregnancy.
登录
查看更多内容
影响因子：
168.9
作者：
Javaid, MK;Crozier, SR;Cooper, C
通讯作者：
Cooper, C
影响因子：
4
作者：
Cooper, C;Eriksson, JG;Barker, DJP
通讯作者：
Barker, DJP
影响因子：
4.7
作者：
Lapillonne, Alexandre
通讯作者：
Lapillonne, Alexandre
影响因子：
6.1
作者：
Erkkola, M.;Kaila, M.;Virtanen, S. M.
通讯作者：
Virtanen, S. M.
DOI：
10.1098/rspb.2003.2502
发表时间：
2003-10-22
影响因子：
4.7
作者：
Neave, N;Laing, S;Manning, JT
通讯作者：
Manning, JT