Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force.
Micro-Dosing of Fine Cohesive Powders Actuated by Pulse Inertia Force.
复制标题
由脉冲惯性力驱动的细粘性粉末的微量定量
DOI：
10.3390/mi9020073
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发表时间：
2018-02-07
期刊：
影响因子：
3.4
通讯作者：
Wu L
中科院分区：
文献类型：
--
作者：
Wang H;Zhang T;Zhao M;Chen R;Wu L
超细粘结性粉末的微量投加是添加剂制造中的关键技术，尤其是在高效活性药物配料(HPAPI)中。然而，高精度微剂量(<；5 mg)的细小粘性粉末就不那么微不足道了，仍然是一个挑战，因为很难消除(在小毛细血管中)强大的颗粒间粘聚力引起的聚集现象。本文提出了一种利用脉冲惯性力系统实现超细粘结粉末微量投加的新方法。压电致动器用于为锥形玻璃喷嘴提供足够高的脉冲惯性力，并借助颗粒自重驱动喷嘴中的粉末颗粒从喷嘴孔中排出。喷嘴的出口直径在100-2000微米范围内是通过玻璃加热工艺制造的。采用α-一水乳糖粉剂作为微量粉剂。研究了锥形喷嘴出口直径、脉冲电压幅值、喷嘴轴线夹角对微量给药质量的影响。对于单脉冲惯性力，最小平均剂量质量为0.6 mg。当剂量质量较小时，代表微剂量稳定性的剂量质量变异系数可控制在5%以下。
Micro-dosing of fine cohesive powders is the key technology in additive manufacturing and especially in high-potency active pharmaceutical ingredients (HPAPI). However, high accuracy micro-dosing (<5 mg) of fine cohesive powder is less trivial and still remains a challenge because it is difficult to eliminate the aggregation phenomena caused by the strong interparticle cohesive forces (in small capillaries). This paper presents a novel micro-dose method of fine cohesive powders via a pulse inertia force system. A piezoelectric actuator is used to provide a high enough pulse inertia force for a tapered glass nozzle and drive powder particles in the nozzle to be discharged from the nozzle orifice with the help of particle self-gravity. The nozzles with outlet diameters in the range of 100–2000 µm were fabricated via a glass heating process. The α-lactose monohydrate powder is used as the micro-dosing powder. The influences of the tapered nozzle outlet diameter, amplitude of the applied pulse voltage, and angle of the nozzle axis on micro-dosing mass are researched. The minimum mean dose mass is 0.6 mg for a single pulse inertia force. The coefficient of variation of dose mass, which represents the micro-dosing stability, can be controlled below 5% when the dose mass is relatively small.
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