Cell adhesion in Drosophila: versatility of cadherin and integrin complexes during development.

Cell adhesion in Drosophila: versatility of cadherin and integrin complexes during development.
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DOI:
10.1016/j.ceb.2012.07.006
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发表时间:
2012-10
影响因子:
7.5
通讯作者:
Brown, Nicholas H.
Brown, Nicholas H.
中科院分区:
生物学2区
文献类型:
--
作者:
Bulgakova, Natalia A.;Klapholz, Benjamin;Brown, Nicholas H.

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我们强调最近的进展,了解钙粘蛋白和整合素功能的模式生物果蝇。这些粘附受体的新功能继续在该系统中被发现,强调细胞粘附在发育中的生物体中的重要性,并显示细胞类型之间对细胞粘附的需求发生变化。已经发现了控制粘附的新方法,包括控制粘附组分的表达和募集、其翻译后修饰、再循环和周转。重要的是,即使是无处不在的粘附组分也可以在不同的细胞环境中发挥不同的功能。
We highlight recent progress in understanding cadherin and integrin function in the model organism Drosophila. New functions for these adhesion receptors continue to be discovered in this system, emphasising the importance of cell adhesion within the developing organism and showing that the requirement for cell adhesion changes between cell types. New ways to control adhesion have been discovered, including controlling the expression and recruitment of adhesion components, their posttranslational modification, recycling and turnover. Importantly, even ubiquitous adhesion components can function differently in distinct cellular contexts.
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