Sodium Leak Channel in the Nucleus Accumbens Modulates Ethanol-Induced Acute Stimulant Responses and Locomotor Sensitization in Mice: A Brief Research Report.
Sodium Leak Channel in the Nucleus Accumbens Modulates Ethanol-Induced Acute Stimulant Responses and Locomotor Sensitization in Mice: A Brief Research Report.
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DOI：
10.3389/fnins.2021.687470
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发表时间：
2021
影响因子：
4.3
通讯作者：
Zhou C
中科院分区：
文献类型：
--
作者：
Wu Y;Zhang D;Liu J;Yang Y;Ou M;Liu B;Zhou C
乙醇可引起动物和人类的急性兴奋反应。此外，反复暴露于乙醇可能会增加其急性运动刺激作用的敏感性，这一过程称为运动敏化。乙醇引起急性刺激反应和自发致敏的分子机制尚未完全阐明。钠漏通道（NALCN）广泛表达于中枢神经系统，控制神经元的基础兴奋性。本研究旨在确定NALCN是否参与乙醇诱导的小鼠急性反应和运动敏化。在这里，我们的研究结果表明，乙醇引起DBA/2小鼠的急性刺激反应。致敏程序后成功诱导了运动致敏。因此，与对照小鼠相比，致敏小鼠的丘脑核（NAc）中NALCN mRNA和蛋白的表达水平显著增加。敲低NAc中NALCN的表达水平减轻了乙醇诱导的急性反应和运动敏化。我们的研究结果表明NAC中NALCN表达的上调有助于乙醇诱导的DBA/2小鼠的急性刺激反应和运动敏化。
Ethanol can induce acute stimulant responses in animals and human beings. Moreover, repeated exposure to ethanol may produce increased sensitivity to its acute locomotor stimulant actions, a process referred to as locomotor sensitization. The molecular mechanism of the development of acute stimulant responses and locomotor sensitization by ethanol is not fully understood. Sodium leak channel (NALCN) is widely expressed in central nervous system and controls the basal excitability of neurons. The present study aims to determine whether NALCN is implicated in the ethanol-induced acute responses and locomotor sensitization in mice. Here, our results showed that ethanol caused acute stimulant responses in DBA/2 mice. Locomotor sensitization was successfully induced following the sensitization procedure. Accordingly, the expression levels of NALCN mRNA and protein in the nucleus accumbens (NAc) were markedly increased in the sensitization mice compared to the control mice. Knockdown the expression levels of NALCN in the NAc alleviated both the ethanol-induced acute responses and locomotor sensitization. Our findings indicate that upregulation of NALCN expression in the NAc contributes to the ethanol-induced acute stimulant responses and locomotor sensitization in DBA/2 mice.
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DOI：
10.1111/j.1530-0277.2007.00518.x
发表时间：
2007-11-01
影响因子：
3.2
作者：
Addicott, Merideth A.;Marsh-Richard, Dawn M.;Dougherty, Donald M.
通讯作者：
Dougherty, Donald M.
影响因子：
5.3
作者：
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通讯作者：
Weiner, Jeffrey L.
影响因子：
3.4
作者：
Kuo CC;Shen H;Harvey BK;Yu SJ;Kopajtic T;Hinkle JJ;Kyrkanides S;Katz JL;Wang Y
通讯作者：
Wang Y
影响因子：
5.3
作者：
Shi, Yingtang;Abe, Chikara;Bayliss, Douglas A.
通讯作者：
Bayliss, Douglas A.
DOI：
10.1111/acer.14553
发表时间：
2021-03-07
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Porru，Simona;Lopez-Cruz，Laura;Correa，Merce
通讯作者：
Correa，Merce