Endogenous glutamate in association with inflammatory and hormonal factors modulates bone tissue resorption of the temporomandibular joint in patients with early rheumatoid arthritis.
Endogenous glutamate in association with inflammatory and hormonal factors modulates bone tissue resorption of the temporomandibular joint in patients with early rheumatoid arthritis.
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DOI：
10.1016/j.joms.2009.04.056
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发表时间：
2009-09
期刊：
影响因子：
--
通讯作者：
Kopp S
中科院分区：
文献类型：
--
作者：
Hajati AK;Alstergren P;Näsström K;Bratt J;Kopp S
本研究的目的是探讨血浆谷氨酸水平与早期RA患者颞下颌关节x线骨侵蚀程度、炎症性疾病活动性以及雌二醇和睾酮之间的关系。47名患者（29名女性，18名男性），其中24名血清阳性，在诊断为RA后不久被纳入研究。通过锥束CT图像记录TMJ骨组织吸收（侵蚀）的影像学征象，并计算每位患者的侵蚀评分（0 - 24）。静脉血类风湿因子、c反应蛋白、红细胞沉降率、白细胞颗粒计数、谷氨酸、雌二醇、睾酮。在适当的情况下，采用非参数和参数统计方法进行分析。大部分患者均有颞下颌关节吸收性改变。血浆谷氨酸水平与放射糜烂扩展之间存在显著正相关，在c反应蛋白、雌二醇或睾酮水平较低的患者中表现最为明显。另一方面，在雌二醇水平高的患者中，糜烂与c反应蛋白相关。c反应蛋白和雌二醇水平低的患者谷氨酸水平最高。本研究表明，大多数早期RA患者表现出TMJ骨组织吸收的影像学征象，循环谷氨酸与这些变化的程度有关。谷氨酸和骨吸收之间的关系似乎受到全身炎症活动以及雌二醇和睾酮水平的影响。
The aim of this study was to investigate the relation between plasma level of glutamate and extent of radiographic bone erosion of the TMJ in patients with early RA in relation to inflammatory disease activity as well as estradiol and testosterone. 47 patients (29 women and 18 men) of whom 24 were seropositive were included shortly after being diagnosed with RA. Radiographic signs of bone tissue resorption (erosions) in the TMJ was recorded by cone-beam CT images and an erosion score (0 – 24) was calculated for each patient. Venous blood was analyzed for rheumatoid factor, C-reactive protein, erythrocyte sedimentation rate, leukocyte particle count, glutamate, estradiol and testosterone. Nonparametric and parametric statistical methods were used in the analysis when applicable. Resorptive changes of the TMJ were found in a major part of the patients. There was a significant positive correlation between plasma level of glutamate and extension of radiographic erosions that was strongest in the patients with low levels of C-reactive protein, estradiol or testosterone. On the other hand erosions were correlated with C-reactive protein in patients with high levels of estradiol. The highest levels of glutamate were found in patients with low levels of C-reactive protein and estradiol. This study shows that a majority of patients with early RA presents radiographic signs of bone tissue resorption of the TMJ and that circulating glutamate is associated with the extent of these changes. The relationship between glutamate and bone resorption seems to be influenced by systemic inflammatory activity as well as estradiol and testosterone levels.
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影响因子：
27.4
作者：
Booij, A;Biewengabooij, CM;Bijlsma, JWJ
通讯作者：
Bijlsma, JWJ
影响因子：
--
作者：
Kramer, PR;Kramer, SF;Guan, G
通讯作者：
Guan, G
DOI：
10.1016/j.tripleo.2004.06.079
发表时间：
2005-04-01
期刊：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
影响因子：
--
作者：
Helenius, LMJ;Hallikainen, D;Lindqvist, C
通讯作者：
Lindqvist, C
影响因子：
20.3
作者：
Riggs, BL;Khosla, S;Melton, LJ
通讯作者：
Melton, LJ
影响因子：
4.8
作者：
Genever, PG;Skerry, TM
通讯作者：
Skerry, TM