Paclitaxel and Urolithin A Prevent Histamine-Induced Neurovascular Breakdown Alike, in an Ex Vivo Rat Eye Model.
Paclitaxel and Urolithin A Prevent Histamine-Induced Neurovascular Breakdown Alike, in an Ex Vivo Rat Eye Model.
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DOI：
10.1021/acschemneuro.1c00692
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发表时间：
2022-07-20
影响因子：
5
通讯作者：
Ganugula, Raghu
中科院分区：
文献类型：
--
作者：
Uppada, Srijayaprakash;Zou, Dianxiong;Scott, Erin M.;Ko, Gladys;Pflugfelder, Stephen;Kumar, M. N. V. Ravi;Ganugula, Raghu
神经血管性眼病的预防比管理或治疗更好。尽管人们越来越关注人口老龄化以及糖尿病和高血压等疾病的继发性发展，但我们目前解决这一全球性问题的选择很少。创建有效和高通量的筛选策略与干预本身同样重要。在这里，我们提出了第一次一个强大的离体大鼠眼模型组胺诱导的血管损伤研究的治疗潜力紫杉醇（PTX）和尿石素A（UA）作为替代地塞米松预防视网膜血管损伤。在组胺激发组中观察到血管化和细胞凋亡的广泛损失，并在干预组中成功预防，在PTX和UA中更显着。这些重要的早期结果表明，PTX和UA可以开发为各种视网膜疾病的潜在预防策略。
Neurovascular eye problems are better prevented than managed or treated. Despite growing concern of occurrence in aging populations and development secondary to diseases such as diabetes and hypertension, we currently have very few options to tackle this global problem. Creating effective and high-throughput screening strategies is as important as the intervention itself. Here, we present for the first time a robust ex vivo rat eye model of histamine-induced vascular damage for investigating the therapeutic potential of paclitaxel (PTX) and urolithin A (UA) as alternatives to dexamethasone for preventing vascular damage in the retina. Extensive loss of vascularization and apoptosis were observed in the histamine-challenged group and successfully prevented in the intervention groups, more significantly in the PTX and UA. These important early results indicate that PTX and UA could be developed as potential preventive strategies for a wide variety of retinal diseases.
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