Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization.
Life stressors significantly impact long-term outcomes and post-acute symptoms 12-months after COVID-19 hospitalization.
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DOI：
10.1016/j.jns.2022.120487
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发表时间：
2022-12-15
影响因子：
4.4
通讯作者：
Galetta, Steven L.
中科院分区：
文献类型：
--
作者：
Frontera, Jennifer A.;Sabadia, Sakinah;Yang, Dixon;de Havenon, Adam;Yaghi, Shadi;Lewis, Ariane;Lord, Aaron S.;Melmed, Kara;Thawani, Sujata;Balcer, Laura J.;Wisniewski, Thomas;Galetta, Steven L.
关键词：
评估COVID-19住院后长期结局预测因素的数据有限。我们对因COVID-19住院的患者进行了一项前瞻性纵向队列研究。在诊断后6个月和12个月收集以下结局：使用改良兰金量表（mRS）评估残疾，使用Barthel指数评估日常生活活动，使用电话蒙特利尔认知评估（t-MoCA）评估认知，焦虑、抑郁、疲劳和睡眠的神经生活质量组合，以及COVID-19急性期后症状。使用多变量logistic回归评估这些结局的预测因素，包括人口统计学、COVID-19前合并症、COVID-19住院指标和生活压力因素。在790名住院存活的COVID-19患者中，451名（57%）完成了6个月（N = 383）和/或12个月（N = 242）随访，77/451名（17%）在出院和12个月随访之间死亡。12个月时，121/239（51%）例患者报告了显著的生活压力。在多变量分析中，生活压力因素包括经济不安全、粮食不安全、密切接触者死亡和新发残疾是mRS、Barthel指数、抑郁、疲劳和睡眠评分恶化以及症状延长的最强独立预测因素，调整后的比值比范围为2.5至20.8。预后不良的其他预测因素包括年龄较大（与更差的mRS、Barthel、t-MoCA、抑郁评分相关）、基线残疾（与更差的mRS、疲劳、Barthel评分相关）、女性（与更差的Barthel、焦虑评分相关）和COVID-19严重程度指数（与更差的Barthel指数、症状延长相关）。生活压力因素在COVID-19住院治疗后12个月显著导致功能、认知和神经精神结局恶化。预后不良的其他预测因素包括年龄较大、女性、基线残疾和指数COVID-19的严重程度。
Limited data exists evaluating predictors of long-term outcomes after hospitalization for COVID-19. We conducted a prospective, longitudinal cohort study of patients hospitalized for COVID-19. The following outcomes were collected at 6 and 12-months post-diagnosis: disability using the modified Rankin Scale (mRS), activities of daily living assessed with the Barthel Index, cognition assessed with the telephone Montreal Cognitive Assessment (t-MoCA), Neuro-QoL batteries for anxiety, depression, fatigue and sleep, and post-acute symptoms of COVID-19. Predictors of these outcomes, including demographics, pre-COVID-19 comorbidities, index COVID-19 hospitalization metrics, and life stressors, were evaluated using multivariable logistic regression. Of 790 COVID-19 patients who survived hospitalization, 451(57%) completed 6-month (N = 383) and/or 12-month (N = 242) follow-up, and 77/451 (17%) died between discharge and 12-month follow-up. Significant life stressors were reported in 121/239 (51%) at 12-months. In multivariable analyses, life stressors including financial insecurity, food insecurity, death of a close contact and new disability were the strongest independent predictors of worse mRS, Barthel Index, depression, fatigue, and sleep scores, and prolonged symptoms, with adjusted odds ratios ranging from 2.5 to 20.8. Other predictors of poor outcome included older age (associated with worse mRS, Barthel, t-MoCA, depression scores), baseline disability (associated with worse mRS, fatigue, Barthel scores), female sex (associated with worse Barthel, anxiety scores) and index COVID-19 severity (associated with worse Barthel index, prolonged symptoms). Life stressors contribute substantially to worse functional, cognitive and neuropsychiatric outcomes 12-months after COVID-19 hospitalization. Other predictors of poor outcome include older age, female sex, baseline disability and severity of index COVID-19.
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影响因子：
7.5
作者：
Akbarialiabad H;Taghrir MH;Abdollahi A;Ghahramani N;Kumar M;Paydar S;Razani B;Mwangi J;Asadi-Pooya AA;Malekmakan L;Bastani B
通讯作者：
Bastani B
DOI：
10.1016/s2213-2600(21)00263-0
发表时间：
2021-10
期刊：
The Lancet. Respiratory medicine
影响因子：
--
作者：
Hinks TSC;Cureton L;Knight R;Wang A;Cane JL;Barber VS;Black J;Dutton SJ;Melhorn J;Jabeen M;Moss P;Garlapati R;Baron T;Johnson G;Cantle F;Clarke D;Elkhodair S;Underwood J;Lasserson D;Pavord ID;Morgan S;Richards D
通讯作者：
Richards D
影响因子：
158.5
作者：
Cavalcanti, A. B.;Zampieri, F. G.;Berwanger, O.
通讯作者：
Berwanger, O.
影响因子：
9.9
作者：
Cella, D.;Lai, J-S.;Moy, C.
通讯作者：
Moy, C.
影响因子：
9.9
作者：
Frontera, Jennifer A.;Sabadia, Sakinah;Galetta, Steven
通讯作者：
Galetta, Steven