The non-human primate model of tuberculosis.
The non-human primate model of tuberculosis.
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DOI：
10.1111/j.1600-0684.2012.00536.x
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发表时间：
2012-06
影响因子：
0.7
通讯作者：
Lackner AA
中科院分区：
文献类型：
--
作者：
Kaushal D;Mehra S;Didier PJ;Lackner AA
非人类灵长类动物（NHP）因其基因组、生理学和免疫系统非常相似而被用来模拟人类疾病。最近，人们对NHP中的结核病（TB）建模越来越感兴趣。猕猴易感染结核分枝杆菌（Mtb）的不同菌株，根据感染途径和剂量，产生全谱疾病，包括潜伏感染、慢性进行性感染和急性TB。显然，NHP是人类结核病的出色模型。虽然NHP模型的最初目的是允许候选疫苗和药物的临床前测试，但它现在也被用于研究发病机制和保护的免疫相关性。本文综述了该领域的最新进展。关键问题，如缺氧对结核分枝杆菌生物学的影响和潜伏性结核病再激活的基础，现在可以通过使用这个模型进行调查。
Non-human primates (NHPs) are used to model human disease owing to their remarkably similar genomes, physiology, and immune systems. Recently, there has been an increased interest in modeling tuberculosis (TB) in NHPs. Macaques are susceptible to infection with different strains of Mycobacterium tuberculosis (Mtb), producing the full spectrum of disease conditions, including latent infection, chronic progressive infection, and acute TB, depending on the route and dose of infection. Clearly, NHPs are an excellent model of human TB. While the initial aim of the NHP model was to allow preclinical testing of candidate vaccines and drugs, it is now also being used to study pathogenesis and immune correlates of protection. Recent advances in this field are discussed in this review. Key questions such as the effect of hypoxia on the biology of Mtb and the basis of reactivation of latent TB can now be investigated through the use of this model.
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影响因子：
3.7
作者：
Geisbert, Thomas W.;Daddario-DiCaprio, Kathleen M.;Broder, Christopher C.
通讯作者：
Broder, Christopher C.
DOI：
10.1073/pnas.201404898
发表时间：
2001-09-25
影响因子：
11.1
作者：
Langermans, JAM;Andersen, P;Thomas, AW
通讯作者：
Thomas, AW
影响因子：
120.7
作者：
Dye, C;Scheele, S;Raviglione, RC
通讯作者：
Raviglione, RC
影响因子：
5.8
作者：
Flynn, JoAnne L.
通讯作者：
Flynn, JoAnne L.
DOI：
10.4049/jimmunol.0804375
发表时间：
2009-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kari L;Whitmire WM;Crane DD;Reveneau N;Carlson JH;Goheen MM;Peterson EM;Pal S;de la Maza LM;Caldwell HD
通讯作者：
Caldwell HD