A single intradermal injection of IFN-γ induces an inflammatory state in both non-lesional psoriatic and healthy skin.
A single intradermal injection of IFN-γ induces an inflammatory state in both non-lesional psoriatic and healthy skin.
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DOI：
10.1038/jid.2011.458
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发表时间：
2012-04
影响因子：
6.5
通讯作者：
Lowes, Michelle A.
中科院分区：
文献类型：
--
作者：
Johnson-Huang, Leanne M.;Suarez-Farinas, Mayte;Pierson, Katherine C.;Fuentes-Duculan, Judilyn;Cueto, Irma;Lentini, Tim;Sullivan-Whalen, Mary;Gilleaudeau, Patricia;Krueger, James G.;Haider, Asifa S.;Lowes, Michelle A.
银屑病是一种慢性、使人衰弱、免疫介导的炎症性皮肤病。由于IFN-γ参与许多细胞过程，包括树突状细胞（DC）的活化、抗原加工和呈递、细胞粘附和运输以及细胞因子和趋化因子的产生，因此产生IFN-γ的Th 1细胞被认为是银屑病发病机制中不可或缺的一部分。最近，IFN-γ被证明可增强DC产生IL-23和IL-1，并随后诱导Th 17细胞，Th 17细胞是银屑病病变中炎症级联反应的重要贡献者。为了确定IFN-γ是否确实诱导在银肩病病变中表达的途径，将IFN-γ的单次皮内注射施用至银肩病患者的临床正常的非病变皮肤区域，并在24小时后收集活组织检查。虽然皮肤没有明显变化，但IFN-γ诱导了许多银屑病病变的分子和组织学特征。IFN-γ增加了皮肤中许多差异表达的基因，包括许多与T细胞和炎性DC流入相伴的趋化因子。此外，在IFN-γ处理的皮肤中存在炎性DC产物TNF、iNOS、IL-23和TRAIL。因此，与健康皮肤相比，在非病变皮肤中显著升高的IFN-γ似乎是可以诱导银肩病的炎性级联反应的许多特征的关键致病细胞因子。
Psoriasis is a chronic, debilitating, immune-mediated inflammatory skin disease. As IFN-γ is involved in many cellular processes, including activation of dendritic cells (DCs), antigen processing and presentation, cell adhesion and trafficking, and cytokine and chemokine production, IFN-γ-producing Th1 cells were proposed to be integral to the pathogenesis of psoriasis. Recently, IFN-γ was shown to enhance IL-23 and IL-1 production by DCs and subsequently induce Th17 cells, important contributors to the inflammatory cascade in psoriasis lesions. To determine if IFN-γ indeed induces the pathways expressed in psoriasis lesions, a single intradermal injection of IFN-γ was administered to an area of clinically normal, non-lesional skin of psoriasis patients and biopsies were collected 24 hours later. Although there were no visible changes in the skin, IFN-γ induced many molecular and histological features characteristic of psoriasis lesions. IFN-γ increased a number of differentially expressed genes in the skin, including many chemokines concomitant with an influx of T cells and inflammatory DCs. Furthermore, inflammatory DC products TNF, iNOS, IL-23, and TRAIL were present in IFN-γ-treated skin. Thus, IFN-γ, which is significantly elevated in non-lesional skin compared to healthy skin, appears to be a key pathogenic cytokine that can induce many features of the inflammatory cascade of psoriasis.
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DOI：
10.4049/jimmunol.181.7.4733
发表时间：
2008-10-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kryczek I;Bruce AT;Gudjonsson JE;Johnston A;Aphale A;Vatan L;Szeliga W;Wang Y;Liu Y;Welling TH;Elder JT;Zou W
通讯作者：
Zou W
DOI：
10.1038/jid.2010.166
发表时间：
2010-11
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
6.5
作者：
FIERLBECK, G;RASSNER, G
通讯作者：
RASSNER, G
DOI：
10.1073/pnas.0409569102
发表时间：
2005-02-08
影响因子：
11.1
作者：
Chamian, F;Lowes, MA;Krueger, JG
通讯作者：
Krueger, JG