Distinct patterns of soluble leukocyte activation markers are associated with etiology and outcomes in precapillary pulmonary hypertension.
Distinct patterns of soluble leukocyte activation markers are associated with etiology and outcomes in precapillary pulmonary hypertension.
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DOI：
10.1038/s41598-020-75654-w
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发表时间：
2020-10-29
影响因子：
4.6
通讯作者：
Ueland T
中科院分区：
文献类型：
--
作者：
Lekva T;Gullestad L;Broch K;Aukrust P;Andreassen AK;Ueland T
炎症过程的激活已被确定为肺血管重构的主要驱动因素，其有助于毛细血管前肺动脉高压（PH）的发展。我们假设，反映单核细胞/巨噬细胞的白细胞活化的循环标志物，（sCD 163、sCD 14）、T细胞（sCD 25）和中性粒细胞（髓过氧化物酶[MPO]，中性粒细胞明胶酶相关脂质运载蛋白[NGAL]）活性，可以提供毛细血管前PH的预后信息。采用酶免疫分析法测定了特发性PAH患者血浆中MPO和NGAL（IPAH; n = 30）; PAH相关疾病患者（APAH; n = 44）和慢性血栓栓塞性PH（CTEPH）患者（n = 32），并与23名健康对照者进行比较。白细胞活化标志物在毛细血管前PH中升高，尤其是在APAH中升高。单核细胞/巨噬细胞标志物sCD 163水平升高与整个组的不良长期预后独立相关，sCD 25水平升高与APAH的不良预后相关，而sCD 163和NGAL水平升高与IPAH和CTEPH的不良预后相关。我们的数据显示，毛细血管前PH中的白细胞活化具有不同的特征，并根据病因对预后产生影响。在完全校正的模型中，sCD 163与不良结局的相关性可能特别令人感兴趣。
Activation of inflammatory processes has been identified as a major driver of pulmonary vascular remodeling that contributes to the development of precapillary pulmonary hypertension (PH). We hypothesized that circulating markers of leukocyte activation, reflecting monocytes/macrophages (sCD163, sCD14), T-cells (sCD25) and neutrophils (myeloperoxidase [MPO], neutrophil gelatinase-associated lipocalin [NGAL]) activity, could give prognostic information in precapillary PH. Circulating markers of leucocyte activation, sCD163, sCD14, sCD25, MPO and NGAL were measured by enzyme immunoassays in plasma from patients with idiopathic PAH (IPAH; n = 30); patients with PAH related to associated conditions (APAH; n = 44) and patients with chronic thromboembolic PH (CTEPH) (n = 32), and compared with 23 healthy controls. Markers of leucocyte activation were elevated in precapillary PH with particularly high levels in APAH. The elevated levels of monocyte/macrophage marker sCD163 was independently associated with poor long-term prognosis in the group as a whole, and elevated levels of sCD25 was associated with poor prognosis in APAH, while elevated levels of sCD163 and NGAL was associated with poor prognosis in IPAH and CTEPH. Our data show leucocyte activation in precapillary PH with different profiles and impact on prognosis according to etiology. The association of sCD163 with poor outcome in fully adjusted model may be of particular interest.
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影响因子：
3.8
作者：
Jasiewicz, Malgorzata;Kowal, Krzysztof;Kaminski, Karol Adam
通讯作者：
Kaminski, Karol Adam
DOI：
10.1161/circheartfailure.115.002225
发表时间：
2015-07
期刊：
Circulation. Heart failure
影响因子：
--
作者：
Nevers T;Salvador AM;Grodecki-Pena A;Knapp A;Velázquez F;Aronovitz M;Kapur NK;Karas RH;Blanton RM;Alcaide P
通讯作者：
Alcaide P
影响因子：
2.6
作者：
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通讯作者：
Austin ED
影响因子：
4
作者：
Nakayama, Wakana;Jinnin, Masatoshi;Ihn, Hironobu
通讯作者：
Ihn, Hironobu
影响因子：
8
作者：
Klinke, Anna;Berghausen, Eva;Baldus, Stephan
通讯作者：
Baldus, Stephan